more on WTA and nicotine (2)

kinabaloo;4512212 said:

It's really good to hear the experiences and that they are so positive.

It appears that the chain vaping nicotine-only till buzzed out is fairly common, and obviously not a good thing. Either the rate of change of x (x being a result of nicotine rather than nic itself) is key to satiation or that x depends not only on nicotine.

Variablity in individual biochemistry is certainly partly controlled by genetics (and epigenetics), so offspring are likely to share traits. Most genetic influence is complex, not the one gene on/off type, and the result is a spectrum.

While the brain is developing, particularly in the womb and the first years, but up to ~20 to a lesser extent, the settings for 'normal balance' and so on are fixed so it is most likely that early exposure will have an impact.

Clearly there are people who do well on just nic and many of them can wean of the nic quite easily too. But there are many others too for which nic-only is at best a partial replacement; and even some for whom the nic will trigger even greater cravings.

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Additional thought: just maybe, long term use of just nicotine might not be good in some way for some people, even if that is only a decline in it's effects when its use is of the slow absorption type. This is just a possibility, but I'm thinking of reports where people who have vaped for many months or a year plus feel it lose effect (my words).

All the toxic stuff aside, smoking 'worked' and it is therefore sensible to duplicate that in a safer alternative (vaping) than to fiddle with it and provide only part. There just might be unintended consequences beyond lowered effectivesness.

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