more on WTA and nicotine

kinabaloo;4510231 said:

It's interesting to ponder that the importance of the other alkaloids might be mainly through their ability to amplify / speed up the nicotine effect; that the problem with NRTs such as the patch, and even traditional e-liquid, is not after all so much that nicotine is not the key, but the importance of rate of change was overlooked. That is, the body reacts to changes more than to absolute levels. Change something too slowly and it goes unnoticed (like the boiling frogs).

That we call some of the other alkaloids MAOIs for their amplifying effect though they have other effects too, but just maybe this attribute of the other alkaloids is the major one.

Individual variability means that the need sfor that boost would vary and this may be more the difference between people than a need for nicotine vs the other alkaloids; some people may naturally react more to less rate of change Just a thought.

In other words, that some of the minor alkaloids are MAOIs is their important attribute / role - and that rate of change is the key.

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MAOIs - Monoamine oxidase inhibitors - slow the destruction of increased levels of dopamine, serotonin and other monoamine 'feel good / alert 'neurotransmitters by inhibiting the oxidase enzyme that performs that role. Hence they both enable a faster rise in the neurotransmitter levels and extend the period of the elevated levels. The fast onset of increase I postulate as important for the reward mechanism involved - the association of cause and effect - and the experience of satiation.

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