WTA : MAOI needs and synergy needs

kinabaloo;4510013 said:

A thought about the role of WTA :

On the one hand, some people may have been more in need of those other alkaloids - the 'relaxing' ones as opposed to the more stimulating effect of just nicotine (an over-simplification for sure, but of some dexcriptive merit).

But besides that is I think the synergy of the two, which in one way creates a bigger 'hit' - that is, a faster effect; and I see this as the satiation effect (one efect of MAOIs is to amplify and extend the increased levels of neurotransmitters such as dopamine). So there could be people for whom the MAOIs are not needed so much for their own effects (anti-anxiety/calming) but for the boost and satiation that they provide when taken together - particularly in the vaping scenario where absorption is slower (in a way it is not the actual levels that are key, but the rate of change).

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