I think that has a lot to do with why e-cigs are so effective for quitting smoking; not only do they supply nicotine, but they cause the same parts of the brain, the "enjoyment" chemicals, to fire, even, apparently, when the other chemicals of cigarette smoke aren't present -- for most people. A few of us need the extra alkaloids, but most seem to do just fine without them.
For me, I think maybe that both the benefit and satisfaction mainly happen immediately with the big breath, throat hit, and visible exhale. I felt no benefit, satisfaction, or craving relief using patches or gum. None. Zero nic vaping doesn't work for me, but might have potential if I were to want to quit nicotine. It would be a challenge without the throat hit, though.
It almost seems like I feel those immediate effects in my brain, possibly via sinuses. It might be because it really relaxes me a lot. It would make sense that it could be felt in the head, similar to how tension and stress can make a head hurt.