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  1. Madame Psychosis

    So - are we getting it or are we not - nicotine

    To follow what TBob says: Stonewalls, like nicotine lozenges, use binders to put the stuff into tablet form. Those minerals/sweeteners/etc. would screw up an atomizer quickly because they don't vape. If they are letting you vape, they may be one of those forward-looking companies that...
  2. Madame Psychosis

    So - are we getting it or are we not - nicotine

    "of course right" doesn't belong before my name. (though it's nice to hear it for the first time :p) We're all trying to figure this out.
  3. Madame Psychosis

    So - are we getting it or are we not - nicotine

    Depends on the person. I'm not sure I know anymore. If the page I found above is correct, then smokeless users aren't getting nearly the MAO inhibition they were getting from tobacco smoke. I think one of the things making this so complex is that the X-factor is somewhat of a moving target...
  4. Madame Psychosis

    So - are we getting it or are we not - nicotine

    Speaking of which... I couldn't resist flipping through the book that Mister linked above. From page 849: Norharman and harman appear to be the two primary culprits for the MAO inhibiting action of tobacco smoke, btw. How much can we get without torching the tobacco? It looks like very little.
  5. Madame Psychosis

    So - are we getting it or are we not - nicotine

    Mister - that's spectacular material and thank you for your keen eye in finding it. Intriguing questions, too. I'm glad you mention again the question of what smoking does to the alkaloid content, because it raises some pretty big questions.(...and I'm liking your signature.)
  6. Madame Psychosis

    808 users and everyone else

    Awesome of you :) I'd like to do a PIF as well... I have ten unopened V4L cartos, 18mg and 24mg, mostly VG cappuccino and premium CMF. I can also send along some TV Tastyfinger 24mg. I'm piggybacking in case there was someone that you couldn't help at the moment but you could direct to me...
  7. Madame Psychosis

    The E-Liquid Swap Thread

    I'd like to trade a near-full (25ml) bottle of German Chocolate Cake made with Choc. No. 712 (instead of Loranns). 12mg, 20% VG. I'd be open to trading for similar quantities (or a combo of a few samples) of pretty much any TV premium flavor besides tobacco or clove. Any mg level is fine. My...
  8. Madame Psychosis

    Natural MAOI ?

    Not a dumb question at all! Irreversible MAOIs form a covalent bond to the MAO enzyme, deactivating the enzyme permanently (the bond cannot be reversed) throughout the body. But, your body keeps synthesizing MAO on a continual basis. So, if you take an irreversible MAOI, and stop it, you'll...
  9. Madame Psychosis

    Natural MAOI ?

    Green tea has very little MAOI action. Otherwise I might be in the ER right now. I am on a pharmaceutical MAOI (under doctor's prescription of course), take a green tea extract supplement (to control my caffeine intake to a precise milligram level, so as not to cause hypertension), and vaping...
  10. Madame Psychosis

    So - are we getting it or are we not - nicotine

    ....and there you go. I know this is a suboptimal place to put all that, but I wanted to drum up comments ("more on this" "less on that" "stop being so long-winded" "WTH are you talking about?" etc.) before trying to create a whole new thread. After all, this thread was a huge collaborative...
  11. Madame Psychosis

    So - are we getting it or are we not - nicotine

    5. Conclusion If you need just nicotine, and the behavioral act of “smoking”, vaping will be plenty. If you need the other alkaloids in tobacco, vaping will not be enough. For those of us in the latter group, we've spent our time in this thread trying to figure out how to regain the...
  12. Madame Psychosis

    So - are we getting it or are we not - nicotine

    4. WTA Liquid – Confirmation of a Hypothesis One of the major turning points in the thread occurred when DVap, using his considerable chemistry background, was able to extract the whole alkaloid fraction from tobacco. This became known as Whole Tobacco Alkaloid liquid, or WTA. The...
  13. Madame Psychosis

    So - are we getting it or are we not - nicotine

    3. Variable Addiction & What Some of Us Need: Consider the variety of backgrounds and personalities that convene on this forum. We all smoked because we all found some kind of satisfaction or balance from smoking. But the “why” of smoking is complicated: some of us smoked to keep away...
  14. Madame Psychosis

    So - are we getting it or are we not - nicotine

    2. The Rest of Tobacco Why do smoking cessation treatments fail so badly for so many? Tobacco research took a wrong turn somewhere, as DVap put it. Smoking cessation treatments focus entirely on nicotine replacement, or in the case of Chantix (varenicline) and Wellbutrin (Zyban, bupropion)...
  15. Madame Psychosis

    So - are we getting it or are we not - nicotine

    Part 1. The X-Factor Does this sound familiar? After two or three weeks of vaping, there’s a sense of depression, anxiety, lack of concentration, or other symptoms suggesting that vaping is not doing the same thing as cigarettes were. Something isn’t right. You might have smoked two...
  16. Madame Psychosis

    So - are we getting it or are we not - nicotine

    I’ve elaborated some points, condensed others, eliminated a great deal of the wonderful conversation within the thread, but this topic is much too important to overlook. The basic ideas: * The thread started with the initial question: are we getting nicotine? DVap has summarized the...
  17. Madame Psychosis

    So - are we getting it or are we not - nicotine

    DVap, thank you. I've been meaning to contact you and say that your excellent summary should probably go out soon whether or not I could get my act together with the MAOI/alkaloid information. It's been a rough winter, well beyond anything I could have anticipated. I think I promised a summary...
  18. Madame Psychosis

    tobacco alkaloid pill?

    I saw this on the New Members Forum too, but thank you for reposting here. This is enormously important work, and I'm glad a company has figured out that it poses a business opportunity as well. I wonder if this will be approached by the FDA as a tobacco product or as a dietary supplement...
  19. Madame Psychosis

    Anyone else drinking less coffee?

    Smoking induces the activity of a liver enzyme called CYP1A2. It seems mostly to be due to certain carcinogens (polycyclic aromatic hydrocarbons) in tobacco smoke, but possibly also nicotine. CYP1A2 metabolizes caffeine. So, more smoking --> speeds up metabolism of caffeine --> you feel...
  20. Madame Psychosis

    DIY nicotine candy

    These tasks may not be suited for microwaves -- the heating can be so uneven (popping, hotspots, god-knows-what leaching from plastic containers) and there's no ability to stir during the process. Double boiler, anyone? I've used it to make candy in the past...common tool for chocolate-making...
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