Charge it when you get it, then use it normally. It will "break in" over a couple of charge/discharge cycles. Do not discharge it fully. Generally, li-ion only tolerate being discharged down to 2.5V. It is best to charge when they are depleted to around 3.2V (or even higher) to preserve cycle life. I usually charge the cells I use in my mech around 3.5V.
Also,li-ions do not have a memory effect, so no worries about topping off the charge whenever. It is somewhat beneficial to the cell (under certain circumstances).
The break in on a new li-ion is just dropping the internal resistance to proper levels and allowing it to reach its full rated charge capacity. This happens after a few usage cycles all by itself.