yeah the high drains are safer because of their structure, they can also handle much higher heat as well as the discharge rate/Amp draw required by a LR atty...
particularly the 16340 size (the 18650 size really isnt a concern)...the amp draw of a LR atty at 3.7V is around 2.7A...at best the max discharge rate of a AW Li-Ion 16340 is 1.5A so that battery is overstressed which will damage the battery and prep it for failure...versus the high drain which is capable of up to 4.4A...
yes there is no PCB in the high drains which means at worst you can over drain the battery which might get to a point where the battery wont take a charge at all..
However, there's also an issue with the Li-Ion where a faoulty charger or static electricity could actually short out a PCB in a Li-Ion with no indication to the user...and that over discharge could have caused plating to build up on the cathodes in the battery preping it for failure...
So now we're down to a Li-Ion and a LiMN that has the same amount of protection (because there are 3 levels of protection in the batteries)... the Li-Ion hits thermal instability at 302 farenheit..the manganese at 482 farenheit....the remaining safty features should stop that before the batteries get to that level unless of course their no name batteries that have skimped on that protection so then it comes down to the venting...Li-Ion batteries create their own oxydizer so they vent with gas and then flames....where the Manganese don't create an oxydizer so they only vent gas...in either case the PTC should catch it before then and stop it..
here: Lithium-ion safety concerns
http://www.batteryuniversity.com/partone-5B.htm
in the section titled Safety level of lithium-ion systems
it covers a portion of how they are safer...
and The high-power lithium-ion
explains the difference in structure of Li-Ion and LiMN
http://www.batteryuniversity.com/partone-5A.htm