A lot of people boil the cartomizers and atomizers once the e-juice has had a chance to build up on the coils. I usually clean mine (or throw them out if i know they are unressurectable lol) after about 2 weeks of use. By then, the coils are coated in dried on e-liquid particulates, the carto is performing poorly from lack of heat, the flavors are mixing from multiple juices, and the draw gets tighter and tighter. If the draw gets very tight, i straiten out a paperclip and I carefully push it through the bottom hole in the battery connection end. That sometimes frees up a bubble of stuck juice and it pours out the bottom end. Then, I either boil my cartos, Or, OR, I do something that hasn't been mentioned here yet. I put them in a cup of clean, scentless, high grade, high content, alcohol. This will surely get rid of any germs lingering in the carto or atty.
But, I for one, believe in germs. I hate overcleaning. I think we all need to be exposed to germs to improve our immune systems throughout life and over cleaning can be harmful to the respiratory system. I wash my hands when they look dirty. I take care when handling raw meats or things known to harbor fatal germs, but I try not to be ..... Germs are good for you.