Hi, welcome to ECF. I'd think your prime would work fine with higher VG liquids. I vape pretty close to max VG (other than flavors) as I am PG sensitive. I found distilled water at 10% to greatly improve my vaping experience, in terms of lower temperatures in my tank (really, the reason I started using it) but I found DW to improve my mixes (flavor, wicking) overall. I'd suggest starting with a few drops of DW in your tank and if you like the results, maybe looking at "setting" a DW percentage for yourself and see how you do. Thinning your vape some will probably improve wicking, I would think, I have found that to be the case in many of my RTAs.
However, if you don't want to use DW at all, you will likely be fine. You may find slightly shortened wick life due to gunking factors, would be my guess.
Best of luck,
Anna