I suffer from knee pain mostly mild but sometimes bad. I've never had a problem with vaping when I take the pill. But two days ago I ran out and decided to use the patch which is strong. Was ok until I vaped and then I just zombied out. It lasted pretty long about a half hour. I took of the patch. Think that is the last time I will be using the patch. I don't know what would have happened if I had been driving. Just though you guys should know. Will be telling my doctor about this too. Oh I was vaping 24mg nic.