If you remove all of the air inside of the syringe when you are withdrawing your liquids, the fluid inside of the needle will remain there when you inject into your mixing container. You will get rid of it when you clean it out. You can get rid of all of the air by withdrawing the plunger...and reinjecting back into the source bottle if there is any air in the syringe in the initial draw. But in all honesty, I would not worry about it one way or the other unless you are making very, very small batches.