No. No liquid leaks anywhere....period. The drip well on the REO was to catch any stray drops of juice that might leak out of an atty.....it was designed back when everyone was using either 510, 306, 801, or 901 attys. With some of those, there might have been a drop or two that would leak out of the atty, so the drip well would catch it. With the RM2, there is no leakage at ALL because of the design. The liquid shoots straight up into the bottom hole of the RM2, out the hole that is right under the coil/wick, saturating it.....the "leftover" juice is caught in the bowl shaped "floor" of the atty and channeled back down the hole and back into the bottle. The cap of the atty screws onto the base and it is a perfect fit, so no juice leaks out there. The air hole on the side of the cap is high enough above the floor that it doesn't leak there (unless you pretty much squonked long enough and hard enough to empty half your bottle into the atty....and even then it drains back down the tube when you quit squonking.) No leaking.
As an added safeguard, there is an o-ring that sits in the bottom of the catch cup around the 510 connection that would keep anything from leaking out if it were so inclined. No leaking. Perfect atty. Perfect mod. Perfect vape.