I loved the original Pico 75, a true 75watt fully regulated mod that fits in the palm of your hand. I didn't like the 22mm (23 actually) tank limitation, my favorite tanks are all 24mm.
Then along came the still tiny Pico 25 which would accommodate larger tanks but it has that swirly plastic inset fingerprint magnet on its sides. I've leaned to live with the plastic swirly things because with them I gained the ability to use my favorite 24mm tanks.
Then came the Pico 21700 which looks just like the original Pico 75 but it's a bit bigger in order to accommodate the larger battery. Personally, I don't know if I'm willing to trade super compact size for a larger battery. I vape between 30 and 40 watts and a 3000mAh 18650 works just fine for me, I don't need the higher amperage a 21700 would provide. Still, I like the original clean look of the 21700, no plastic swirly things.
The new Pico S is larger in size much like the Pico 21700 but it's "glitzy" and should appeal to anyone who likes glitzy gear. Not really my cup-o-tea but I like that Eleaf is always innovating its products, gives me hope for the future.