I mix with 100mg/mL nic and this gives me quite a bit of leeway PG/VG wise because it is so concentrated. I can imagine that if you were starting with a low mg/ml it would take up a lot of space in your juice. If your base is 50 % of the whole mix and the flavoring is another 20% of the whole mix, there wouldn't be much room left for adjusting the PG/VG ratio. It seems to me that the 50/50 nic base would give you some PG/VG leeway in this instance. When I first started mixing my own juice, it took awhile to figure out that I like a 50/50 ratio. I was glad that the 100mg/mL gave me the space to experiment. I work with dangerous stuff and I am used to the precautions that need to be taken, so I didn't have issues with the 100mg/mL when I began mixing. I can imagine that some might prefer to work with lower concentrations.