No proof on one being safer than the other.
PG is a better flavor carrier, thinner, lower viscosity, and adds to the
throat hit of nicotine.
VG is thicker, provides denser clouds, has a creamy and sweeter taste, and can give you wicking issues with several things.
PEG, polyethylene glycol, is really popular in Europe, but it hasn't gain much traction in US. Based by forum information, it offer some of the best aspects from both VG and PG. I'd like to try it... no time for diy.
I use a lot of ratios, but I tend to keep my PG at 50%or less.. only reason I use higher PG mixes is because some vendors I use mix that way. I don't believe in asking for anything different, since liquids are tailored to those ratios. I don't get anything from vendors that offer multiple mixes, outside of darkest day vapors.