I've been using 50/50. I was talking with some folks this morning at the local vape shop about this very thing. One guy told me that 100% PG caused him to wind up with a bloody nose from the dryness of it, and if he used straight VG he felt like he'd been hitting vegetable oil. That was his experience, not mine. I haven't started mixing my own juice yet, but eventually I will, and I'll experiment a little. For now, 50/50 seems just fine to me. Good vapor, good TH. I usually use 12 or 16 nic, by the way.