There are mods in here that use AAA, AA, +.
I think the benefit of going with a single battery is that it takes up less volume for the same amount of mah. The quality of some of these larger
batteries are quite good too. I have AW brand 18650(new) from lighthound.com and they run at 4.2 volts (even though its rated at 3.7). These last 1.5 days per charge, easy ( I have not actually went so far as to vape until it was completely gone).
A benefit of using standard sized batteries is that you do not have to purchase specialty batteries, and probably have stuff in your home you could take apart to fit them or create the housings.
Hope this helps.