The only advantage I can see is if your favorite mix is 50/50, you
vape it unflavored and your nic preference is exactly the one you are purchasing. If you are looking for any kind of DIY where you have to cut it down and add flavors, 50/50 has no advantages for me. My favorite is 100% pg, so it is easy for me to make it 75/25 with the use of any diy calculator, some VG and a few flavors.