I think of it like this: the space in which music is played makes a huge difference in sound quality, right? They build those crazy styrofoam rooms in recording studios for a reason.
I think this analogy carries over to atomizer chambers. The inside of my Kayfun chimney looks very different from the inside of my dripper, and it affects the characteristics of my vapor. I can't say exactly what variables affect a certain characteristic, but there is a pretty significant difference for me, even with essentially identical coils, at the same wattage. Probably airflow is the biggest contributor, though: whether it comes from below the coil, beside the coil, and the amount of air, is typically pretty different.