I've tried 2 slot, 1 slot, big slots, little slots & not sure why, but they always flood on me. Some juices I could get to work ok with one slot, but they still flood on me after vaping a few ml's. All I use is 100% vg & only use 1 punched hole in my boge's. Larger for thick juice like boba's. Even with 2 holes I get gurgling & spitting after a while. For me 1 hole makes the carto last a lot longer. I use a M1A1, big daddy, SS Dct Map, & a siam tank with the new thicker orings.
Odd for me because I've tried everything & found 1 punched to work the best. It's funny to see people use 2 slots because I can't do that in any of my tanks & make the carto last at least 30ml's.
As a side note: I honestly believe when you slot a carto, your get a little metal in the filler which could in turn be inhaled. JMO.