I fly often, often enough to be Platinum with Delta. I have never had an issue with any of my ecig stuff. I put my tanks and eliquid bottles in the plastic zip lock bag with my other liquids and send it through on the conveyor belt. TSA has seen plenty of ecigs. In all of my trips only once did TSA ask a question, he just wanted to know how it worked, etc...
If you place any extra batteries in your checked luggage instead of your carry on, make sure they are packaged in a protective case. One of those plastic cases all the ecig vendors carry is perfect.
Some tanks leak due to cabin pressure. Either use a plastic bag or wait until the cabin is pressurized to fill the tank. This way you will be ready to vape as soon you are off the plane and out of the airport.