No yes, it has more to do with what one prefers. I prefer higher VG so I mix my
juice at 70% VG. Find it smoother and more flavorful. I find high PG is to harsh. That said, it depends on the individual. Some are intolerant to PG, some to VG. Took me awhile to find my true
vape, but now I stick with 70-80% VG.