Hi Bad Habit, organic flavors tend to be more heat sensitive than artificial flavors, so high voltage or any set up that heats them up too much can tend to kill the flavor. They won't stuff up your atty though. I've used them in 510 atties and cartos and enjoy both. I carry the Boge and Sapphire cartos because I particularly like my flavors in them, but I know that customers use all kinds of set ups. As long as you stay away from too high of voltage, you should be able to enjoy them!