I'll give it a try.
Nicotine produces a throat hit, but compared to an analog, it doesn't have quite the right "feel", not the same "tingle and "burn". Alkaloids are simply the psychoactive components of tobacco, possessing alkaline properties due to the way nitrogen is incorporated into the molecules. These alkaloids tend to individually possess a potent taste and smell. When we smoke an analog, all of these alkaloids hit the throat, and collectively are responsible for what we perceive as the throat hit.
Compare the throat hit of an analog versus an e-cig to to a well seasoned soup versus a soup seasoned only with salt. The nicotine is the salt, the fundamental seasoning. It provides much of what is needed, but it can't do the job by itself. It needs some help from other seasonings to provide the rounded flavor that is desired. These other seasonings are the minor alkaloids present in tobacco.
Gotcha!! Now if I up my nic level, I vape 36mg, since it has a taste of its own it will somewhat mess with the taste of my juice. So therefore I need to decide whats more important to me: good throat hit with a little flavor difference or keep my great tasting flavors and forget trying to get that throat hit?