Atreides, in case you might still be following this thread, you certainly introduced a very different view on the significance of blood nicotine levels. As far as I understand, you suggested that blood nicotine levels are low, not because ecig nicotine delivery is less effective, but because binding of ecig-derived nicotine to brain receptors is exceptionally highly effective. Is there any indication that nicotine, once absorbed in blood, would be more preferred from brain receptors if nicotine is derived from pharmaceutical products, compared to nicotine from analog cigarettes? Does the Kd change depending on the delivery system? What exactly did you reference to when you gathered “from the (very sparse, we really need more peer-reviewed data from scientists unconnected with the e-cig industry) data, almost all of the nicotine absorbed through vaping interacts with receptor, as opposed to nicotine levels remaining high in the blood, as with smoking.“?