Lower resistance usually means thicker wire, so more coil mass, and yes there will be a difference depending on how different the coils are.
For example, if you use a 1.8ohm coil, made of 32g Kanthal, at 20 watts it will likely be really hot and sharp(almost acrid) tasting. If you use the same 20 watts on a 26g 0.9ohm coil it will be cooler and likely produce more vapor.
If you meant the same gauge wire also, it will depend even more on the type of coil and the wattage you're using.