Does nicotine slow the healing process ?
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I am not a doctor and I am suggesting that no one interpret my choices as medical advice.
According to wikipedia
So I'm assuming that since blood carries the nutrients needed to heal bone, it makes sense that nicotine would slow down the healing process.
Personally, I follow a regiment of circulatory exercises for my own healing processes. And now that I no longer inhale the damaging smoke of analog cigarettes, my ability to exercise has increased and I heal faster.
According to wikipedia
So I'm assuming that since blood carries the nutrients needed to heal bone, it makes sense that nicotine would slow down the healing process.
Personally, I follow a regiment of circulatory exercises for my own healing processes. And now that I no longer inhale the damaging smoke of analog cigarettes, my ability to exercise has increased and I heal faster.
And now for something we all wanted to hear.....
Nicotine Accelerates Angiogenesis and Wound Healing in Genetically Diabetic Mice
Johannes Jacobi*, James J. Jang*, Uma Sundram, Hayan Dayoub*, Luis F. Fajardo and John P. Cooke*
From the Division of Cardiovascular Medicine*and the Department of Pathology,Stanford University School of Medicine, Stanford; and the Veterans Affairs Medical Center,Palo Alto, California
Recently, we have discovered an endogenous cholinergic pathway for angiogenesis mediated by endothelial nicotinic acetylcholine receptors (nAChRs). Since angiogenesis plays a major role in wound repair, we hypothesized that activation of nAChRs with nicotine would accelerate wound healing in a murine excisional wound model. In genetically diabetic and control mice full-thickness skin wounds (0.8 cm) were created on the dorsum and topically treated over 7 days with either vehicle (phosphate-buffered saline, PBS) or nicotine (10-8 mol/L, 10-9 mol/L; each, n = 5). Wound size was measured over 14 days followed by resection, histological analysis, and quantitation of vascularity. In diabetic animals an agonist (epibatidine, 10-10 mol/L) or antagonist (hexamethonium, 10-4 mol/L) of nAChRs as well as the positive control basic fibroblast growth factor (bFGF, 25 µg/kg) were also tested. To further study the role of endothelial nAChRs in angiogenesis, we used an ex vivo vascular explant model. In diabetic mice wound healing was markedly impaired. Nicotine significantly accelerated wound healing as assessed by closure rate and histological score. The effects of nicotine were equal to bFGF and were mimicked by epibatidine and blocked by hexamethonium. Histomorphometry revealed increased neovascularization in animals treated with nicotine. Furthermore, capillary-like sprouting from vascular explants was significantly enhanced by nicotine. In conclusion, agonist-induced stimulation of nAChRs accelerates wound healing in diabetic mice by promoting angiogenesis. We have discovered a cholinergic pathway for angiogenesis that is involved in wound healing, and which is a potential target for therapeutic angiogenesis.
(American Journal of Pathology. 2002;161:97-104.)
© 2002 American Society for Investigative Pathology Regular Articles
Nicotine Accelerates Angiogenesis and Wound Healing in Genetically Diabetic Mice
Johannes Jacobi*, James J. Jang*, Uma Sundram, Hayan Dayoub*, Luis F. Fajardo and John P. Cooke*
From the Division of Cardiovascular Medicine*and the Department of Pathology,Stanford University School of Medicine, Stanford; and the Veterans Affairs Medical Center,Palo Alto, California
Recently, we have discovered an endogenous cholinergic pathway for angiogenesis mediated by endothelial nicotinic acetylcholine receptors (nAChRs). Since angiogenesis plays a major role in wound repair, we hypothesized that activation of nAChRs with nicotine would accelerate wound healing in a murine excisional wound model. In genetically diabetic and control mice full-thickness skin wounds (0.8 cm) were created on the dorsum and topically treated over 7 days with either vehicle (phosphate-buffered saline, PBS) or nicotine (10-8 mol/L, 10-9 mol/L; each, n = 5). Wound size was measured over 14 days followed by resection, histological analysis, and quantitation of vascularity. In diabetic animals an agonist (epibatidine, 10-10 mol/L) or antagonist (hexamethonium, 10-4 mol/L) of nAChRs as well as the positive control basic fibroblast growth factor (bFGF, 25 µg/kg) were also tested. To further study the role of endothelial nAChRs in angiogenesis, we used an ex vivo vascular explant model. In diabetic mice wound healing was markedly impaired. Nicotine significantly accelerated wound healing as assessed by closure rate and histological score. The effects of nicotine were equal to bFGF and were mimicked by epibatidine and blocked by hexamethonium. Histomorphometry revealed increased neovascularization in animals treated with nicotine. Furthermore, capillary-like sprouting from vascular explants was significantly enhanced by nicotine. In conclusion, agonist-induced stimulation of nAChRs accelerates wound healing in diabetic mice by promoting angiogenesis. We have discovered a cholinergic pathway for angiogenesis that is involved in wound healing, and which is a potential target for therapeutic angiogenesis.
(American Journal of Pathology. 2002;161:97-104.)
© 2002 American Society for Investigative Pathology Regular Articles
Hi ..new here
You probably allready know this...but here goes anyway...It is a well established fact, that the intake of nicotine prevents and protects against dementia of the alzheimers type.......it is also proven to protect against colon cancer (so not all bad)
If Alzheimers is prevalent in your family, it could be a very good idea to vape some nicotine on a daily basis.
It takes a fool to remain sane....and I am no fool.
You probably allready know this...but here goes anyway...It is a well established fact, that the intake of nicotine prevents and protects against dementia of the alzheimers type.......it is also proven to protect against colon cancer (so not all bad
)If Alzheimers is prevalent in your family, it could be a very good idea to vape some nicotine on a daily basis.
It takes a fool to remain sane....and I am no fool.
OOH and by the way...It is true that smokers when undergoing surgery, produces scars that are twice as big as non-smokers......HOWEVER.....there is no scientific evidense that this is also true for vapers !
I really dont think we have even scratched the surface of harmfull effects from smoking....and what the h....are they adding to the tobacco ? I am affraid we will never know....and I am sure I dont dare to be in the know...having smoked the deadly stuff for 31 years.
it takes a fool to remain sane....and I am no fool
I really dont think we have even scratched the surface of harmfull effects from smoking....and what the h....are they adding to the tobacco ? I am affraid we will never know....and I am sure I dont dare to be in the know...having smoked the deadly stuff for 31 years.
it takes a fool to remain sane....and I am no fool
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