Personally, I have never seen the need to oxygenate/shake premixed nicotine base.
Just like the alcohol in beer, the nicotine does not normally fall out of the pg/vg solution.
I've never had a problem with them myself, but then again I do use PG-based nic and shake it before use.
I'm inclined to agree with you that hotspots are not as likely to develop as people think, assuming you start with a homogeneous solution, but I don't know enough (and perhaps I should look into this) about the chemistry of nic in VG to be sure.
I can tell you that shaking flavorings is absolutely necessary, but that's because some constituents of certain flavorings do tend to fall out of a PG solution- you can hold some flavorings to the light and see with the naked eye different indices of refraction after they've sat for a while. In extreme cases you can see layers after the constituents have separated.
The thing is, I'm not sure that the nic you get from every vendor is a homogeneous solution in the first place. Even if nic is very unlikely to _develop_ hotspots I don't think it that unlikely that it could come with some.
And, the consensus among experienced mixers seems to be that nic can develop them- that might be nonsense, but I'm less inclined to dismiss, out of hand, claims like that from people with significant experience than I might once have been.
EDIT: Also, you don't shake your beers thoroughly before use? SMDH and YDIWIFYKWIMAITYD.