I usually remove the tank, and open it up as though I was going to refill it. I pour the liquid back in the bottle it came from, and then rinse the tank with warm tap water. If I don't want to have a mix of the flavors, I open up the RDA, and pull the wick out, do a couple of dry burns on the kanthal coil, and then pop in a new wick. Saturate the wick with the new liquid, fill the tank with the new liquid, put it all together, and enjoy. If I don't care if the flavors mix, I don't re wick. I have also purchased a couple of extra RDAs for the subtanks mini, since they are only 6 or 7 bucks, and will sometimes just switch out the RDA rather than re wick.