A safe alternative, or a risky experiment?

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Placebo Effect

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Pretty poor article from Fredericksburg, VA

Fredericksburg.com - A safe alternative, or a risky experiment? - page 1 FLS

Snippets below

When Wayne Gilmer wanted to cut back on cigarettes about seven months ago, he ordered a trendy product to help him out. It didn't involve a patch or a pill, and it looked like a regular cigarette.

The item? An electronic cigarette.

. . .

The federal Food and Drug Administration has warned that e-cigarettes may contain toxic chemicals and increase the risk of nicotine addiction among young people.

"They are poorly studied," said Dr. Tim Sherwood, who treats patients with lung cancer and other illnesses as a thoracic surgeon at Mary Washington Hospital in Fredericksburg. "And there is no true regulation regarding their production or distribution."

For Gilmer, who had smoked for 45 years, the experiment with e-cigarettes didn't go well. The amount of nicotine in the product he tried felt like too much, he said.

"It made my lungs raw," the 55-year-old Spotsylvania County resident said. "I really didn't like it."

Gilmer also said he developed headaches after trying e-cigarettes. He's now in a smoking cessation support group and takes Chantix, a prescription anti-smoking pill, which has helped.

"I've been four months now without anything, without needing to smoke," Gilmer said.

. . .

But health officials locally and around the country are skeptical of the product's safety and say people who want to give up cigarettes shouldn't consider e-cigarettes a good option.

'PEOPLE ARE MISLED'

FDA research on two popular brands of the product found traces of toxic chemicals, including ones known to be carcinogenic
, the agency reported. Also, the FDA said nicotine levels were different than what the label claimed in some products.

Eletta Hansen, tobacco treatment specialist at Mary Washington Hospital, said she worries about the lack of conclusive research into the products' safety.

"For me, the downside is that people are misled by advertising and invest in a product that we do not know works," Hansen said.

Hansen said she'll offer support to people who want to give the devices a try [Better than nothing], but she will recommend only FDA-approved methods to those trying to quit.

"To quit smoking they have to believe in the method," Hansen said. "So if they believe in it I will support it, but I cannot endorse the use."

. . .

"For some, they say it works," Hansen said. "But others say it makes them want to smoke more."

. . .

Dr. Thomas Eissenberg at Virginia Commonwealth University has studied electronic cigarettes.

"I would not recommend those or any new products until I know they are safe," Eissenberg said.

He said he "definitely" thinks the products should be regulated by the FDA.

"It is clear right now that we have products with variable content," Eissenberg said. "We just don't know what they could be contaminated with."

Sherwood, the thoracic surgeon, is also concerned about the chemicals in electronic cigarettes and does not recommend the devices to patients.

"There are chemicals in it that we know to be detrimental to the human body," Sherwood said. "Patients think that since it is not the 4,000 plus chemicals in cigarettes it's safe."

But much is unknown about the products, he said. Sherwood is also concerned about teenagers who may begin smoking e-cigarettes and get hooked because they think the devices are safer than traditional cigarettes.

The devices do not violate Virginia's ban on indoor smoking, according to Virginia Attorney General Ken Cuccinelli. But, Sherwood said, "I have to believe there is some secondhand smoke with these. The problem is that we don't know what secondhand effects they produce."

. . .

The bottom line, according to Eissenberg: "We don't have the data to believe they are safe, and we don't have the data to believe they are not. This is not the kind of wait-and-see experiment I want to see the American people participate in."
 

Placebo Effect

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I sent two e-mails to the author

Ms. Brady,

Having just read your article on the e-cigarette, I must express my disappointment in your failure to put the FDA's claims about the e-cigarette in perspective. Using the FDA's own data on carcinogens found in the e-cigarette, one would have to use 1000+ e-cigarette cartridges to inhale the number of carcinogens in a SINGLE Marlboro light. The number of carcinogens found by the FDA was equal to those found in the patch. Both the DC District Court and DC Court of Appeals have both noted, in ordering the FDA to stop seizing e-cigarette shipments using the argument that e-cigarettes are unregulated 'drug delivery devices,' that the FDA has failed to demonstrate that the products are dangerous.

Additionally, I wish you would have consulted and referred to Dr. Michael Siegel's article on the e-cigarette for the Journal of Public Health Policy, which is the most recent, most comprehensive look at studies that have been performed on e-cigarettes. I've attached it. The article demonstrates that there is absolutely no reason to belief that e-cigarettes are not significantly safer than smoking, and that there is preliminary evidence to support a finding that they are more effective than the patch, gum, etc., which have success rates at 20 months as low as 2-5%.

I quit smoking overnight with the e-cig 5 months ago, and do not regret it.

Ms. Brady,

My apologies for sending a second e-mail.

One other note about your article -- you quote a local man who said that he felt he was getting too much nicotine from the e-cigarette, and you also interview Dr. Jesse Eissenberg. Dr. Jesse Eissenberg's sole published study on the e-cigarette demonstrated that e-cigarettes are actually poor deliverers of nicotine. I believe his quote was something like, "They're about as effective [at nicotine delivery] as sucking on a fake cigarette." I wish you would have pointed this out.

Thank you

Edit: It's Dr. Tom Eissenberg, not Jesse.
 
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Placebo Effect

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And to Dr. Sherwood

Dr. Sherwood,

I was very disappointed to see your recent comments in this article about the electronic cigarette, namely concerning the "detrimental" chemicals found in the e-cigarette and its supposed appeal to teenagers.

Firstly, none of the 15 lab tests that have been performed on e-cigarette liquid has found chemicals in quantities that are dangerous to the human body. The FDA's press release regarding their testing highlighted two items. (1) E-cigarettes contain carcinogens, and (2) E-cigarette contain diethylene glycol, a chemical found in antifreeze. What the FDA failed to note (and this isn't surprising considering they were and still are involved in a lawsuit with manufacturers) was that the amount of carcinogens found in the liquid tested was equal to that of the patch. In other words, one would have to use 1000+ e-cigarette cartridges to inhale the number of carcinogens that they would in a SINGLE cigarette. Secondly, the amount of diethylene glycol found ("approximately 1%" in one of the nineteen cartridges they tested) would not be harmful to rats, let alone humans.

I certainly hope that you do not consider propylene glycol, which has been used in asthmatic inhalers for 50+ years without significant issue, and nicotine, which is of course in nicotine replacement therapy products, to be dangerous chemicals.

Additionally, no study has ever demonstrated that a single teenager uses e-cigarettes, nor has any study demonstrated that the product is attractive to teenagers. The costs of using an e-cigarette are front-loaded. For me to start it cost me approximately $75. How many kids do you know that have access not only to $75, but a credit card?

I've attached a recent article from the Journal of Public Health Policy by Dr. Michael Siegel. It is the most recent and most comprehensive analysis of all known tests that have been performed on the e-cigarette. Dr. Siegel concludes that there is no reason to believe that the product is not significantly less harmful than smoking, and notes that the product has tremendous potential to get people off of cigarettes, something that traditional NRTs fail to do up to 97% of the time after 20 months.

I have not smoked a single cigarette in the past 5 months because of my e-cigarette. Had the FDA been able to take the product off the market and force manufacturers to spend millions to be approved as a drug delivery device, absent illegal ordering I would not have obtained an e-cigarette. I had no plans to quit smoking before I learned about the e-cigarette, and would very likely be continuing to slowly kill myself had I not discovered it.

Thank you,
 

akoaysigod

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I haven't read into too much about the safety about ecigs but it can't be worse than regular smoking. And as far as chantix goes...

Side effects:

Constipation; gas; headache; increased appetite; nausea; stomach upset; strange dreams; taste changes; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur when using Chantix:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); behavior changes; chest pain; fainting; fast, slow, or irregular heartbeat; hallucinations; memory loss; new or worsening mental or mood problems (eg, aggression, agitation, anger, anxiety, depression, nervousness, thoughts of hurting other people); red, swollen, blistered, or peeling skin; seizures; severe or persistent nausea; suicidal thoughts or actions; trouble sleeping; vision changes; vivid, strange, or unusual dreams.

I mean some of those are regular symptoms of quitting smoking but some of them sound fairly bad, although these are somewhat rare, I think. It's hard to find any really non-biased information on Chantix via google, its also almost 6 here and I'm pretty tired and not trying very hard. Either way, I'd rather take my chances with vaping vs this. Besides, its success rate isn't that great anyway.
 

Vocalek

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I have sent a rather lengthy email message to Dr. Tom Eissenberg. A few excerpts:

Your quote is misleading. “We don’t have the data to believe they are safe” implies that any product that could be effective in helping people give up smoking--a practice that kills >400,000 U.S. citizens per year---must meet a standard of absolute safety before you could recommend that smokers use it. Have you ever heard of “Tobacco Harm Reduction”? The idea here is any substitute for smoking does not need to be 100% safe. It only needs to be safer than continued smoking! Switching to smokeless tobacco products would reduce the tobacco-related death toll to about 6,000. The attitude of tobacco prohibitionists seems to be “If you refuse to give up tobacco altogether, we prefer that you continue to use only the most dangerous form. If you die an agonizing early death as a result, we’ll convince ourselves that it was totally your own fault.” In other words, “We are not satisfied with reducing the death toll by 99%. It’s 100% or nothing.”

You don’t like the “wait-and-see experiment” that about a million former smokers are participating in. Instead you prefer the “wait-and-see” experiment that the FDA, ALA, AHA, ACS, CTFK, WHO, AMA, and other groups impose on smokers. “Wait until e-cigarettes are declared 100% safe. Meanwhile keep on smoking those regular cigarettes for another 8 to 10 years until some company spends a billion dollars to get them approved as a new drug.”

Tom, if your parents had smoked for decades and had tried various products and methods but kept relapsing, would you prefer that they continue smoking for many more years until e-cigarettes are declared 100% safe? Or switch ASAP to a merely 90-99% safer e-cigarette?

I am very disappointed in your attitude ... If you were misquoted, please let us know what you actually said to the reporter.
 

Placebo Effect

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It really makes me think about putting the effort in to get down to Virginia to take part in the doctor's study. Why bother when the end result is likely going to be, "Electronic cigarettes deliver nicotine less effectively than the patch and gum, and there is no regulation to ensure the product is safe, and no tests that demonstrate the product is safe." What's the point of giving up my time and literally my blood when Dr. Eissenberg seems content to spin facts negatively?
 

Vocalek

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Before you make up your mind, let's see how Dr. E responds. It is possible that he was misquoted. According to Storyspnr, the reporter has a very negative opinion of e-cigarettes. Perhaps she did not report the whole truth about her conversation with Dr. E.

I didn't know that before I wrote to him. I did let him know in no uncertain terms that if he truly believes that it is safer for people to "just keep smoking" that I would not be recommending that vapers cooperate in his research.
 

throatkick

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Before you make up your mind, let's see how Dr. E responds. It is possible that he was misquoted. According to Storyspnr, the reporter has a very negative opinion of e-cigarettes. Perhaps she did not report the whole truth about her conversation with Dr. E.

I didn't know that before I wrote to him. I did let him know in no uncertain terms that if he truly believes that it is safer for people to "just keep smoking" that I would not be recommending that vapers cooperate in his research.

The FDA "spun" their findings. Why is it so weird that someone else will spin?
 

PlanetScribbles

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others say it makes them want to smoke more

I'd just love to know how it's possible to have a Marlboro and a KR808D1 in your mouth at the same time!
I find it impossible to smoke simultaneously while i'm vaping. No matter how hard I try, it does nothing for me.

For Gilmer, who had smoked for 45 years, the experiment with e-cigarettes didn't go well. The amount of nicotine in the product he tried felt like too much, he said.

"It made my lungs raw," the 55-year-old Spotsylvania County resident said. "I really didn't like it."

He smoked for 45yrs and now his lungs are raw? OK, now the punchline? ...
 
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