All the tobacco companies are developing their own brands and are publicly traded. But the most profit to be made is still in the cottage industry. But, most of the current businesses don't need further investment. They have been so successful they've already paid back their investors and don't really want to share their profits with you. You can fund a new start-up in an area without a brick-and-mortar store. If you can find that market, and good people with the basic lab skills and professionalism necessary, you can invest in them.