Nic needs to be kept in the freezer if you are not going to use it up within a few months. Some folks refrigerate PG and VG but it's not mandatory. I
buy nic in 1 L bottles and break it up into 3 - 250 ml and 2 - 125 ml glass bottles and only keep one 125 ml bottle out at room temp at a time. That's a 2 - 3 month supply for me and I've never had any problems with it going bad. Make sure there is as little air room in the frozen bottles as possible and that the caps are good and tight.