I've wondered the same subject in a slightly different way. Rather than chemists in particular my mind went to scent specialists (which are chemists in a broader
sense). Perfume makers, for example. Wine makers, for another. Aroma is in their playbook in a major way.
My reason for giving think time to this is a little quiz I've given myself as an exercise: What smells have most attracted me throughout my life? Could any of them be replicated in a
vape juice?
Here's a slight digression so please bear with me and I'll soon get back to the point: I've ridden a motorcycle for the last 20 years or so. As my rides became more wide-ranging I soon noticed the smells that I passed through. How they were so varied depending on the place, season, temperature, elevation. On a fast moving bike they hit you in an ever changing barrage. Just one for example: Not just new-mowed hay but hay
being mowed. The scent is fresh and powerful.
Another, the smell of an infant, of milkiness and baby powder combined into a uniquely recognizable scent found nowhere else. One more: A slight breeze off a clean bay at low tide, not the heavy version, but the light taste of salt and seaweed, clam and oyster.
Back on point: Could an expert vape mixer replicate any of this? Would there be a market for any of it but a freak like me?
My list keeps growing. It's not that I'm not happy with what's out there. Coffee, Vanilla, Pastries, Tobacco, Candies, etc., --like 'em all. Just wondering how far, as you put it, a chemist could go.