A little random opinion post here. I've got the iStick 50 as well as a Tesla 120w (compare to a Sigelei, different chip but amazing how consistent the vape is between my Tesla & my roomie's Sig 150...but that's a different post, lol) - anyway - which is better? I LOVE THEM BOTH!!!
Ohm range is close to the same, at least on the lower end- iStick 0.2-5.0, Tesla 0.18-3.0
Power is obviously different, 50w vs 120w, however unless you're super sub ohming (I mean this as under .3ish) I doubt you'll use the difference. (I know OP knows this, I say it for others who may read this thread.)
Battery life is actually about the same. Let me clarify what exactly I mean here. Tesla is a dual 18650, I'm personally using mostly Samsung 25r's (although I also have a set of authentic Sony VTC5s that are really not much different on battery life) - iStick, of course, is what it is. Currently I've got a 0.5 clapton coil Lemo 2 rta on the iStick, and a 0.5 dual micro coil Tobh rda on the Tesla. (Yes, I can drip on the iStick & use the tank on the Tesla, I just usually don't.) Either will last me from 5am til about 6-7pm, and yes I vape way too much as everyone is quick to point out. Lol.
When the batts die, either mod can still be used - iStick via pass thru USB charging, Tesla of course via changing the batts out. However battery safety means that for the iStick I don't use the pass thru much, and that for the Tesla I actually keep 3 sets so that they never, absolutely never go straight off the charger into the mod...they always sit hours first.
In my experience both read ohms accurately. I've built from 0.3 up to 2.8, singles, duals, quads, micro, spaced, nano, twisted kanthal, clapton, you name it... There's never been above a 0.1 difference between them, nor between they & my ohms meter, and even that much of a discrepancy happens rarely. (Especially when you consider both mods round to the tenths place! Each time I've seen a different reading, the meter has said either x.x4 or x.x6 ohms.)
I will say the iStick seems to run a bit higher than its displayed voltage. This is just my opinion, because if I swap the attys & duplicate v/w settings, it seems just a bit warmer on the iStick than the Tesla.
Both of these have been dropped before, BTW, and they both still work just fine

actually, neither have even so much as a scratch, but I'm afraid to say that out loud!
At the end of the day the choice is yours. The Sigelei 50 you're looking at (or any other external battery device) would mean more to keep up with, in terms of batteries/charger/et al, as well as almost certainly a larger device. The iStick frankly people don't seem to think is as "cool" or as "beastly" of a mod, but it does all the same things and frankly is about half the price or less once you add up everything you need to make it turn on. Makes it my going-out mod, and the Tesla my "I wanna feel like a bad*** sitting on my couch" mod. But that's just me

I'd recommend any of these 3 devices -iStick 50, any Sigelei, or the Tesla that I love - with no qualms whatsoever.
Vape on!!