Harvard Eliquid Study Today

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skoony

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Actually, in order to make the claim of "100.0000000000%" it IS necessary. You see that number has several more zeros in it than the number one billion. It therefore asserts a level of certainty requiring exactly that.
It's not necessary if one uses the proper statistical analysis.
I'm sure some have been done. But how many, and were they diligently looking for the somewhat subtle difference between BO and COPD?

Oh, and BTW, what is the causative agent in COPD? Have you considered the possibility that the diketones present in cigarette smoke may play a role in COPD?
Why else would the perform a biopsy? Identify the disease and the severity of the disease in order to select
the best course if any of the treatment. Of course one would have to assume that the technicians doing the lab
work were properly trained and supervised. I'm betting most were.
I personally have not considered the possibility that diketones may cause COPD but, I don't seem to be alone
in overlooking that possibility. I guess all those clinical study technicians overlooked it too.
:2c:
Regards
Mike
 
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StaceyB

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A good friend of ours who is going through a really rough time posted (on FB) yesterday that he got his first mod and is working to be cigarette free. Quite a few people replied with good wishes and such. One person replies and says to stop vaping, it has formaldehyde, it will cause popcorn lung and that people who vape are at a greater risk for cancer.
I was really frustrated when I saw that.
 

DC2

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I wonder if a random smoker checks in on some of the sub-forums here, they think we are all conspiracy theorists.
I have no doubt that most people would think that at first.
In fact, I'm sure all of us "conspiracy theorists" thought that at first too.
;)
 

Jman8

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Unfortunately Siegal blog is biased. He conveniently missed info that some juices are as bad as cigarettes in terms of diacetyl.
We learn we unfortunately cannot really believe not only anti-vaping researchers, but and pro-vaping bloggers also.

I've actually learned (from vaping science) that science can no longer be fully trusted. I had suspicions before vaping, but now when I look at science outside of vaping, it strikes me as obviously biased.

What would possibly be helpful in this discussion, and for sake of good ol' fashioned genuine science is if we had a baseline of non-biased scientific research. If anyone can provide that, here or in PM, I'd be very open to looking at it. I think (or more like hope) it still exists, and so do think it can possibly be found. Currently, I'm under the impression it cannot be found. Just the whole hypothesis aspect of science makes for inherent bias. Conclusions in a scientific report, tend to make it obvious.
 

DC2

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I've actually learned (from vaping science) that science can no longer be fully trusted
I liked your post, but must respond just a bit to the part above...

Science can be trusted, but not scientists, scientific journals, or the media.
Unfortunately, much of what we see these days is not real science.
 

Jman8

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What I don't understand is vapers who make excuses for those vendors in the industry who continue to sell products with high levels of diketones in them, without disclosing that fact, or who've gone as far as hiding that fact and outright lying to their customers.

I don't find this too challenging to either explain or to justify. But I strongly believe if I provide explanation to you on this, it'll be a day or week (at most) where you'll make the same claim, of not understanding how vapers make excuses.

But I'll bite anyway, because I see this near the core of the issue and where things were in industry right before the big blow up (that we have now).

I just got done saying that science cannot be fully trusted. That's a bit soundbite, but is a challenge I put forth, kinda like your challenge to justify why vapers would defend industry. And it relates to this point, for me, because I don't think any vendor (in any industry) can be fully trusted. As in, every product in its marketing contains aspects of deception, if not outright lies. While I think this is highly pertinent to your point, I also think it is too blanket of an assertion to get to the specific type of 'lie' that you are addressing.

The more specific ways that I would make excuses, or properly defend vendors are:
1. Vendors are getting their diketone laced products from other suppliers and have been told that supply did not contain diketones, therefore passing along misinformation. I think in the most prominent case facing vaping vendor today, this is the case (up to a point in time).
2. I think vendors were making the claim of "we don't intentionally add this to our eLiquids." Yet, if it is found in the eLiquid, then that comes off as (outright) lying, and yet given the actual assertion they made, and likely marketed, then they were actually (likely) telling the truth.
3. I think of it as foolish to make the claim in the first place and mostly filter it through (insane) desire to be politically correct, in a vaping reality that circa 2012, saw it as beneficial to make claims of diketone-free liquids. Because we are talking about micrograms, of stuff that can come from their suppliers and can occur naturally (thus all not really known to vendors), I think it was likely to bite some vendors in the ..... My cynical side says you deserve to have it bite you in the .... if you are wanting to go out on the PC limb and make such a, rather pointless, claim. I guess this isn't great defense of vendors, but is an indirect one as I think it is how witch hunt got going early on. Which was later fueled by the Dr. F. study where we got to see 75% had it in there while claiming it wasn't, but of course the good doctor wasn't going to tell us which ones, cause you know, we need to do our own hunting.
4. So, then enter the age of testing for this specific compound (all 750 micrograms of it) and how do you not defend not doing this test when you are making billions of dollars? This, to me is the PC tangent pushed to its next logical step, while also just further setting up the industry to take a fall. Cause some tests are better than others. And so then we have to argue about validity of tests, all while we get to nail vendors on idea of "see! You have it in there! I knew it! I am so cool for being right." And while it might have some benefit to some consumers in a free market arena to substantiate the presence, or lack thereof, for this compound PLUS have benefit to do valid testing (whatever that currently means), the key aspect of these last 2 points is being the vaper(s) in the arena who are defending against the very obvious witch hunt that is taking place.
5. Cause in current scientific reality, the hunters have ZERO claim toward actual harm that comes from this compound as it relates specifically to vaping, and yet are persisting in direction of, 'we don't need you anti-vapers, we can take this on ourselves. We can weed out all the bad players on our own, cause we're good like that. Oh wait, you have some ANTZ-friendly lawyer types that will assist us? Where do we sign up?!'
6. And so with looming regulations, that have been looming since around 2009, it would be very unwise for any vendor to make this claim (either way) and let vapers who are on such a hunt decide if vaping is for them or not, given the uncertainties and/or insecurities they currently have. But as that didn't happen, and many did make the claim, then pro-vaping enthusiasts need to make a decision, do I generally want to side with industry that is squarely in the sights of anti-smoking, anti-vaping people (who are not vapers) or do I want to side with the hunters that Dr. F. nudged along in an effort to "remove all diketones from the industry?"
7. Even while I am convinced, to this moment, that Dr. F. never meant for consumers to be on the witch hunt, and yet due to his insane language of "should be removed," left the door wide open. To which I walked through and felt it very necessary to defend vendors from what amounts to JUNK SCIENCE BY @KFarsalinos (by saying what 'should' occur).
 

Alien Traveler

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I've actually learned (from vaping science) that science can no longer be fully trusted. I had suspicions before vaping, but now when I look at science outside of vaping, it strikes me as obviously biased.

What would possibly be helpful in this discussion, and for sake of good ol' fashioned genuine science is if we had a baseline of non-biased scientific research. If anyone can provide that, here or in PM, I'd be very open to looking at it. I think (or more like hope) it still exists, and so do think it can possibly be found. Currently, I'm under the impression it cannot be found. Just the whole hypothesis aspect of science makes for inherent bias. Conclusions in a scientific report, tend to make it obvious.
Actually, you are talking not about real science here. It's all done on technician level with interpretation of politicians.
If you want to get feeling of real science, read something on physics, mathematics, chemistry... may be even biology.
 
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Jman8

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Actually, you are talking not about real science here. It's all done on technician level with interpretation of politicians.
If you want to get feeling of real science, read something on physics, mathematics, chemistry... may be even biology.

IOW, anything not involving consciousness/behavior? A domain that science would do well to stay out of, or realize it is open to criticism(s) that some of its proponents felt it was overcoming.
 
I liked your post, but must respond just a bit to the part above...

Science can be trusted, but not scientists, scientific journals, or the media.
Unfortunately, much of what we see these days is not real science.

Thank you. Although even when "not trustworthy," it's correctable if done properly. Anybody could theoretically reproduce the conditions as outlined and get the same results. If that doesn't happen, something is awry.

Now as to whether the outlined conditions are realistic is another question. Certainly I wouldn't dream of vaping a cartomizer or basic clearo at 5 volts, so I should never see any appreciable formaldehyde complexes.

One tends to see the most egregious errors when the scientist(s) running the experiment have a starting bias that isn't carefully controlled. Non-peer-reviewed studies are also problematic as the biases can be (and often are) caught by independent review.

These are things that even the most casual experimenter has to account for. In my case, I have a few known biases that I have to control (or have others monitor) when testing plant growth impacts. That's easy...it's the biases that I have but don't even consider that could be an issue! Fortunately, I'm a casual tester but do have a minor name in some very limited circles.
 
Another minor thought is that there's often a slip betwixt the cup and the lip...or in this case, the report and the media.

Let's face it, if it bleeds, it leads. "E-Cigs Really Rather Safe" wouldn't gather a lot of eyes, and there are certainly plenty of articles and studies that show this. The ones that scream, "E-Cigs May Kill You!" get the eyeballs.

Frankly, reading most popular science articles is enough to make me slightly nauseated. If you step back to the basic study, half of what the article says is happening never actually happened...at least not in the manner described.

Translating complex science to the general (and extremely scientifically ignorant) masses is a very rare skill. Neil Tyson has it in astrophysics, but most science writers simply don't and don't have any background in the sciences. They're just a junior reporter.
 

DC2

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One tends to see the most egregious errors when the scientist(s) running the experiment have a starting bias that isn't carefully controlled. Non-peer-reviewed studies are also problematic as the biases can be (and often are) caught by independent review.
When I did my Honors Thesis on the psychology study I performed, and upon which my thesis was based on...

My discussion of potential confounding factors was by far the largest part of the paper.
And that is how it should be in real science.
 

Jman8

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OMG...Dr F sited a study that shows that reduced lung function has been demonstrated by those who inhale diketones. There you go, a test study sited by Dr. F in his research paper... what more proof do you need that reduced lung function has been demonstrated. Yes, i said OP but i meant a poster who later posted in this thread about having problems after vaping high diketones...i am sure everyone can figure out who i was referencing since that discussion made up a chunk of this thread discussion...clearly you missed that discussion apparently. I think it's also note worthy to take into account that all respiratory diseases have advancing stages so when we start seeing early symptoms, such as ones a poster stated they were experiencing earlier in this thread, that should be a red flag. Diketones can cause lung problems on various levels not just popcorn lung disease.
Geesh!!

To the poster who posted about his health problems..... i am glad you did some research and found the link to your respiratory problems and stopped the use of diketones before it further deteriorated you lungs. Hopefully you and others who come on here sharing your story will bring awareness to others who are not aware of the potential risk and concerns raised regarding vaping diketones. I hope it's not too late to reverse the damage and wish you well moving forward as you heal. Hopefully your efforts will help to advance vaping in a positive direction where safety comes first before politics, and that vaping as a safer alternative continues to evolve and improve for all vapers, and not be hindered as it always does due to blinding agendas and politics on both sides.

First point: seems like a serious moving of goalposts to go with "reduced lung function" vs. irreversible condition (aka BO). Anyone think vaping unflavored at 1000 puffs a day for decades will not result in any reduction of lung function? Anyone? How about just breathing normal, small sized city air? Oh wait, that would be a compounding factor to the vaping thing, but let's keep them completely separate (along with the other 50 compounding factors) and blame it entirely on that 1 month to 3 year period where the person (gasp) vaped flavors.

Second point: if it is BO we are talking about, then what type of reversal are you referring to? Can we have it both ways? Can someone stop vaping diketones now after a few months of vaping them and smoking them for decades and reverse the damage? If yes, then let's have that discussion.
 
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DC2

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Seeking truth is what real science is.
Encouraging others to find holes in your theory or process is what real science is.

Trying to shut down dissenters is not what real science is.
Like the ANTZ do, and have been doing for decades.


Trying to mislead through biased conclusions is not science.
It's simply trash, and should be disposed of as such.

The raw data can usually be of some value though, from a scientific perspective.
But even that needs to be viewed through a lens of potentially biased data gathering.

And more and more, I'd be tempted to use the word "probable" instead of "potentially" in that last statement.
 
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Alien Traveler

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IOW, anything not involving consciousness/behavior? A domain that science would do well to stay out of, or realize it is open to criticism(s) that some of its proponents felt it was overcoming.
My take on it is: if something does not employ scientific method - then something is not real science.

Pretty short description of scientific method is here: Introduction to the Scientific Method

I. The scientific method has four steps
1. Observation and description of a phenomenon or group of phenomena.
2. Formulation of an hypothesis to explain the phenomena. In physics, the hypothesis often takes the form of a causal mechanism or a mathematical relation.
3. Use of the hypothesis to predict the existence of other phenomena, or to predict quantitatively the results of new observations.
4. Performance of experimental tests of the predictions by several independent experimenters and properly performed experiments.

... What is key in the description of the scientific method just given is the predictive power (the ability to get more out of the theory than you put in; see Barrow, 1991) of the hypothesis or theory, as tested by experiment. It is often said in science that theories can never be proved, only disproved. There is always the possibility that a new observation or a new experiment will conflict with a long-standing theory.

We can see that vapology (as well as dietology, global warmingology, politology) are not real sciences.

If science is not yet "real science" it does not mean it should be thrown away. It usually means that it is still underdeveloped and is in a stage of gathering primitive information. For example: I have found something new. I want to know what happens if I kick it: will it roll away, will it squeak, or will it bite my leg off. After being dismissed from emergency room I can publish results and be happy that I put my small pebble into foundation of some future theory.
 
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Mazinny

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Or perhaps you simply miss understand that Saying there is No conclusive studies is not the same as saying anyone believes any of this is 100% safe.

I preach Proof constantly, Yet I DIY and choose carefully. My decision and My choice.
I Believe in Honesty and full disclosure.
If you claim it is safe it better be - Safer, well, that falls under subjective.
If you claim it is Deadly - Show Proof.

Articles in social media are not proof.
Court Case rulings are not proof.
CDC limitations for workplace safety are not proof.

Scientific study and documentation brings proof.

So, bring me proof...........or allow me my educated choices.

This is from NIOSH Blog November 10th, 2008 9:23 am ET

{NIOSH is continuing to evaluate new information pertaining to the risk of respiratory disease from occupational exposures to flavorings. Several efforts are underway to investigate exposures, improve sampling methods, evaluate engineering controls, use animal toxicology models to study a range of flavorings and determine how lung injury occurs, disseminate important public health information, and determine appropriate steps to help safeguard workers’ health. More information can be found on the NIOSH Flavorings-related Lung Disease topic page.}

Where are the Results? If humans in an industrial setting can reach critical health is a few short years, the Rats should have croaked in a Few short months.
I won't really comment on the first part of your post ( since i don't really disagree with most of what you wrote ). If anything the fact that you are vociferously arguing against a point i didn't make ( that there is proof of harm ) kinda furthers my point. I will say however, that not only am i in favor of you being allowed your " educated choices " , i would gladly champion your right to make " uneducated choices " as well.

As to your question, a quick google search would have provided you with some answers. The animal toxicology studies subsequent to Nov 10 , 2008, have been published. I won't do your homework for you, but i can nudge you in the right direction. Many of theses studies are cited in the following draft ( especially in Chapter 4, pages 89-113 )

http://www.google.com/url?sa=t&rct=...PQ9cse1nFLDnmZC9w&sig2=jkSpU4srK8MhIvvKg_2kyA
 
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crxess

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I won't do your homework for you, but i can nudge you in the right direction. Many of theses studies are cited in the following draft ( especially in Chapter 4, pages 89-113 )

Don't expect you to. Have had this in my Studies folder.......... along with over 80 other information files to date.
Can't spend my life focused on on subject. Otherwise, why bother living.

It seems the industry is attempting to Prove OB is brought on by DA/AP rather than acknowledging in relation to Air Quality, it is another Irritant on the list, worse in Powered form according to NIOSH Published information.

The same goes for hundreds of other DRY irritants. Everything from fine dust to grinding/crushing of shell products.(Nuts/Beans/etc.)

Once more - I am also 100% for Air quality control in the Work environment.

I doubt you would ever find me advocating Vaping custard flavors as an ADV, however I have yet to see reason for suspecting occasional indulgence is cause for alarm.

2 fingers Vodka in 10oz. Orange juice - yes
12 oz. Everclear - Pass
Moderation :cool:

* Simple question - Microwave Popcorn, incredible popularity in the early days of marketing. An inexpensive Family snack frequently enjoyed.

Where are the Millions of exposed consumors now suffering OB?

Yes, I have had my nose in more than a few bags.;)

Still waiting on scientific medical research establishing conclusive results to inhalation exposure. :unsure:
 
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Jman8

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Seeking truth is what real science is.
Encouraging others to find holes in your theory or process is what real science is.

Trying to shut down dissenters is not what real science is.
Like the ANTZ do, and have been doing for decades.


Trying to mislead through biased conclusions is not science.
It's simply trash, and should be disposed of as such
.

The raw data can usually be of some value though, from a scientific perspective.
But even that needs to be viewed through a lens of potentially biased data gathering.

And more and more, I'd be tempted to use the word "probable" instead of "potentially" in that last statement.

I get this is what ANTZ does, not many will dispute this.

But how do you argue against "should be removed?" Is this not a biased conclusion? I see it as simply trash and should be disposed of as such.
The counter argument is "should be allowed," but how would science go about establishing that? Show me that methodology.

As it stands right now, it should be/is allowed, because scientific evidence has not risen to level of viable concern. Nor addressed the many counterpoints, such as what @VNeil has raised in this thread. Speak to those concerns before you go on prattling about potential concerns. Until you do, your conclusion ought to be disposed of for the trash that it is. All your other points in your study are open to consideration, but deserve equal scrutiny if it is all leading to justification that is clearly biased.
 
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DC2

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But how do you argue against "should be removed?" Is this not a biased conclusion?
The word "should" is not a valid word in real science.
Science has no business rendering judgment, only laying out the numbers.

I'm pretty sure you understand that...
But just wanted to use your post to make a point.
:)
 
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