Help with non vaper needed please.

[Johnny2puffs]

I have an argument on a Fishing Forum on e-cigs and this is what he posted. Can someone help with an answer please.



What you are promoting here is not a harmless hobby. Nicotine on its own still causes increased blood pressure, heart disease, over inflation of the lungs and more and more evidence of cancer and the worst part is it is highly addictive.

The tobacco industry has for years now made use of pseudo science and other BS spin doctoring to make people believe smoking is not so harmful and this is clearly been done by the e-cigarette business. Herewith some extra reading

Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis - Nature Medicine

One of many and this is from Nature which is the authoritive scientific journal. Try Google Scholar for info it sort of cuts through the propaganda and spin doctoring a bit and goes straight to peer reviewed journals. Also important to remember is that there are vast libraries that are not available on Google with even more research on nicotine.

Clinical Pharmacology & Therapeutics - Abstract of article: Nicotine absorption and cardiovascular effects with smokeless tobacco use: Comparison with cigarettes and nicotine gum

And more:


http://www.sciencedirect.com/science/article/pii/S073510979700079X



4.1. Hemodynamic Actions of Nicotine.The hemodynamic effects of cigarette smoking appear to be mediated by nicotine. Intravenous nicotine, nicotine nasal spray and nicotine chewing gum all acutely increase heart rate up to 10 to 15 beats/min and increase blood pressure up to 5 to 10 mm Hg, responses similar to the effects of cigarette smoking ( [62], [63] and [64]). Transdermal nicotine appears to cause lesser acute hemodynamic changes than smoking ([32]).
Nicotine increases cardiac output by increasing both heart rate and myocardial contractility. Nicotine gum chewing has been shown to aggravate regional myocardial hypoperfusion in patients with known coronary artery disease ([65]). Nicotine constricts some vascular beds, such as the skin. Cutaneous vasoconstriction explains the reduction in fingertip skin temperature that is seen with administration of nicotine ([63]). There is evidence that cutaneous vasoconstriction is modulated at least in part by release of vasopressin because the effect was inhibited by administration of a vasopressin antagonist ([66]). Nicotine appears to dilate other vascular beds, such as skeletal muscle ( [67] and [68]). Skeletal muscle vasodilation may in part be a result of the increase in cardiac output, although animal studies suggest that release of epinephrine from nerve terminals may also contribute ([13]).

Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells.

Signalling pathways involved in nicotine regulation of apoptosis of human lung cancer cells.

1. W L Heusch and R Maneckjee

+ Author Affiliations

1. Division of Surgical Oncology, Oregon Health Sciences University, Portland 97201-3098, USA.

Abstract Although nicotine has been implicated as a potential factor in the pathogenesis of human lung cancer, its mechanism of action in the development of this cancer remains largely unknown. The present study provides evidence that nicotine (a) activates the mitogen-activated protein (MAP) kinase signalling pathway in lung cancer cells, specifically extracellular signal-regulated kinase (ERK2), resulting in increased expression of the bcl-2 protein and inhibition of apoptosis in these cells; and (b) blocks the inhibition of protein kinase C (PKC) and ERK2 activity in lung cancer cells by anti-cancer agents, such as therapeutic opioid drugs, and thus can adversely affect cancer therapy. Nicotine appears to have no effect on the activities of c-jun NH2-terminal protein kinase (JNK) and p38 MAP kinases, which have also been shown to be involved in apoptosis. While exposure to nicotine can result in the activation of the two major signalling pathways (MAP kinase and PKC) that are known to inhibit apoptosis, nicotine regulation of MAP (ERK2) kinase activity is not dependent on PKC. These effects of nicotine occur at concentrations of 1 microM or less, that are generally found in the blood of smokers, and could lead to disruption of the critical balance between cell death and proliferation, resulting in the unregulated growth of cells. The findings suggest caution in the use of smokeless tobacco products to treat smoking addiction, as they could have a potentially deleterious effect in patients with undetectable early tumour development.

 

[mikkey9]

Well waded through all that double talk and got to the final sentence:-

The findings suggest caution in the use of smokeless tobacco products to treat smoking addiction, as they could have a potentially deleterious effect in patients with undetectable early tumour development.

translation:-
The findings "suggest" (no proof)
"they could have" (no proof)
"potentially" (no proof)

and all of this only if you`ve already got a tumor.
Maybe you should point out that even if all of it was proven fact, Vaping would still be many times less damaging than smoking

 

[mwa102464]

Send you fishing buddy this = Is nicotine getting a bad rap? – Health – Lifestyle – New Zealand Listener

 

[Vocalek]

Neal Benowitz, the editor of the book Nicotine Safety and Toxicity gave a presentation to the FDA during a public hearing on long-term use of NRTs. Because the directions say to stop using NRTs after a few months, there are no long-term clinical trials on NRTs themselves. So he looked to the several decades of research on health effects on smokers who switched to Swedish snus (a type of moist tobacco). Here is a link to the presentation, posted on the FDA web site: http://www.fda.gov/downloads/Drugs/NewsEvents/UCM232147.pdf

Salient points:

The lack of increase in common cancers in lifelong ST users indicates that nicotine is not a general cancer promoter.
Nicotine may slightly increase the risk of MI and stroke. If so the risks are far lower than those of cigarette smoking.
Nicotine likely has adverse effects on reproduction, including increasing the risk of pre-eclampsia and preterm birth,

ST = Smokeless Tobacco
MI = Myocardial Infarction (commonly referred to as a "heart attack")
Pre-eclampsia = elevated blood pressure in a pregnant woman.

 

[Johnny2puffs]

Thank you for your input. I pasted a link to this on the fishing forum.
What I found interesting is that New Zealand research. I totally agree. I now sometimes forget to vape for hours. Even after meals or coffee when I used to crave a ciggie. Now I don't. So perhaps they are correct by stating that nicotine in conjunction with some other chemical in cigarettes is what makes it addictive. Perhaps I'm addicted to the ACT of smoking now. I will try decreasing my nicotine to 10mg and then to zero and see.