No. My 10 ml bottle of Gandalph that had been forgotten, untouched, on the back of the shelf for over a month tastes/vapes exactly like the bottle of Gandalph that I was opening, shaking, using, every day from day 1. Apparently, Brownian Motion works just as well and something does not need to be openend and shaken every day to reach the same end result after a month or so
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