Atomizers aren't really just like a carto without filler, they're designe a bit differently. Atomizers have a heating coil but wrapped inside it is a small bit of wicking material that absorbs some
juice. Wrapped over the top is a metal mesh called a bridge that is meant to absorb liquid from a cartridge and allow it to seep into the wick. Some people de-bridge their atty's and this is supposed to make the flavor of the
juice cleaner, I haven't found a lot of difference though. You can also buy de-bridged atty's so if you want to try it, that's probably the easiest way since it's easy to ruin an atty when taking the bridge out.
With new atty's it's important to blow out any primer fluid that the manufacturer puts in there. It won't hurt you but it tastes nasty for a long time if you don't get it out. Just put your drip tip on it and blow through it with a tissue on the other end of the atty to catch any liquid that you blow out. Keep blowing hard through there until no more liquid is coming out.
Once it's a clean as you can get it, screw the atty onto your battery just like you do a carto. Add 5 or 6 drops of juice if it's a new atty and let it sit for a couple of minutes to allow the juice to get inside and absorb into the wick. Take a light hit without inhaling and see whether it tastes good, if it's nasty and harsh you may not have gotten all the primer fluid out and you'll have to vape through it. Take a few more hits and cautiously inhale. When the taste gets to where you think it ought to be you're ready to vape. Some atomizers come without primer and you won't have to go through this process. With those just drip 5 or 6 drops and you're pretty much ready to vape. I've been buying the Vapor Kings 510 and 901 atty's and they don't have primer in them.
On a used atty when switching flavors just blow out any remaining liquid just like above, add your new flavor and you're ready to vape. There will be some mixing of flavors when you add the next one, but vape through it and the second fill should be cleaner. When sampling several flavors, start with the weakest one first and work your way up to the strongest. Some flavors will hang in an atty for days so keep that in mind too. Menthol, cinnamon, strong fruit flavors, all stay around for way too long it seems. Some people have several atty's going at once for different flavor types. One for menthols, one for fuits, another for desserts, etc. That helps keep flavors from contaminating others that just don't go together very well.
Well, I hope that help. If you have anymore questions let us know.