How much of the nic actually reaches your blood...

[Vapinginjapan]

As many of you know, nicotine is a lethal poison at very small quantities. However, what less people might know, is that nicotine, despite boiling at 250c, also burns at EXTREMELY low temperatures. (Vapors can burn at 35C/95F, lower than the temperature of the human body)

According to wikipedia, in the nicotine article, a lethal dose can be as low as 50mg. I'm pretty sure there are people who vape more than that on a regular basis here. Nicotine has a half life in the body of about 2 hours, and a bioavalaibility of less than 50% when taken non intravenously, so their nicotine level at any given moment is probably well below this threshold, but l'm still of the impression that the lethal dose is dramatically higher than the threshold for negative effects to kick in.

Given that the lethal dose for caffeine is about 50x higher than the threshold for significant effects, I would wager that not much of the original 32MG in a ml actually make it into the system.


Any thoughts on the matter?

 

[KreeL]

Sounds about right to me.

 

[linnx]

These measurements would have to be taken with blood testing. Vape, draw blood, analyze. Vape some more, draw blood, analyze some more...

 

[mastervapor]

Whatever.

 

[chief druid]

i'm a prime candidate for blood testing ... i love my 36mg ... if anyones worried about vaping to much take solice in the fact that i vape pretty much consintley on 36mg ... i am trying to go lower with tasty flavours .. thinking i will vape it more because its nice ...

 

[yvilla]

According to wikipedia, in the nicotine article, a lethal dose can be as low as 50mg.

Any thoughts on the matter?

One thing you don't seem to have factored in - that lethal dose measurement is for ingestion, and all at once. Big difference between that and inhalation, over a period of time.

That said, I do agree with you that unpleasant symptoms of an overdose would kick in at far less than a "lethal" dose.

 

[Vapinginjapan]

Actually, I don't think it's for ingestion, I think it's for injection.

I'm sure ingestion would have a significantly lower bioavaliability, and thus would require more.

 

[taz3cat]

I did read that they put 10mg of nictoine in a cigarette and when it is burned we only get about 1.5mg.

 

[Skad]

I'm going to assume you're right about the lethal dose being as low as 50mg.
That being said, we're all smokers, and with building an addiction, you also build a tolerance.
But even the folks who vape 36mg aren't vaping a ml all at once, so it's a slow process. I'm sure there's a chance it might kill you if you drank a few ml of it straight down, but I don't think you could vape it fast enough to kill you, even with the overpowered mods they run.

 

[taz3cat]

I have spilt it on me, I have got it in my mouth and vaped it and it has not killed me yet. I think.

The most prescribe blood thinner is rat posion, warfarin.

 

[yvilla]

Actually, I don't think it's for ingestion, I think it's for injection.

I'm sure ingestion would have a significantly lower bioavaliability, and thus would require more.

Well, at the sources I looked at, the LD50 for humans is estimated (of course), but extrapolated from tests with animals, where the LD50 figures did come from oral delivery. Eg:

Nicotine (PIM)

Or,

"The oral LD50 for nicotine is >5 mg/kg in dogs and >24 mg/kg in rodents. Death is due to respiratory paralysis. The oral minimum acute lethal dose for nicotine in adult humans is reported to be 40 to 60 mg (<1 mg/kg). The effects of using several cartridges in rapid succession are unknown (See WARNINGS, Safety Note Concerning Children)."

DailyMed: About DailyMed

 

[Bryn]

My 15 month old dog (big dog - Beauceron breed) got hold of brand new bottle of 24mg of Johnson Creek Cured Tennessee, bit off the top, spilling it in the carpet, she got some in her mouth..leaving approx. 1/4 in the bottle. I was really freaked out when I saw what happened when I came in from walking my other dog. She got it from end table. She vomited twice. It happened last Friday night. I was going to rush her to ER animal hospital, but she was fine after throwing up. I gave her 2 bowls of milk and French bread, then she played with my other dog. I kept checking on her all night and next morning, she showed no ill effect from it. Now it's 5 days and she's fine. I have to be very careful with e-liquid stuff and keep them out of their reach.

 

[king2062]

My 15 month old dog (big dog - Beauceron breed) got hold of brand new bottle of 24mg of Johnson Creek Cured Tennessee, bit off the top, spilling it in the carpet, she got some in her mouth..leaving approx. 1/4 in the bottle. I was really freaked out when I saw what happened when I came in from walking my other dog. She got it from end table. She vomited twice. It happened last Friday night. I was going to rush her to ER animal hospital, but she was fine after throwing up. I gave her 2 bowls of milk and French bread, then she played with my other dog. I kept checking on her all night and next morning, she showed no ill effect from it. Now it's 5 days and she's fine. I have to be very careful with e-liquid stuff and keep them out of their reach.

ack! yeah I have 2 dogs and get paranoid with the juice around them. I would panic if this happened to me.

 

[Kate]

ASPCA Tips to Manage a Poison Emergency

INGESTION:

* Immediately remove the patient/victim from the source of exposure.
* Ensure that the patient/victim has an unobstructed airway.
* Do not induce vomiting (emesis).
* Patient/victims often vomit spontaneously.
* Only if airway is secured administer charcoal as a slurry (240 mL water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents, 25 to 50 g in children (1 to 12 years), and 1 g/kg in infants less than 1 year old.
* Do not administer antacids; alkaline conditions improve the absorption of nicotine.
* Monitor heart function and evaluate for low blood pressure (hypotension), abnormal heart rhythms (dysrhythmias), and reduced respiratory function (respiratory depression).
* Evaluate for low blood sugar (hypoglycemia), electrolyte disturbances, and low oxygen levels (hypoxia).
* If evidence of shock or low blood pressure (hypotension) is observed, begin intravenous (IV) fluid administration. If fluid administration fails to reverse hypotension, dopamine and norepinephrine may be used.
* If seizures occur, treat them with benzodiazepines.
* Maintain adequate hydration and urine output.
* Seek medical attention immediately.

The Emergency Response Safety and Health Database: Systemic Agent: NICOTINE

 

[Bryn]

So far my Beauceron dog named Shania is doing great. Thank you for that link.

I still can't believe she's fine When I was smoking analogs, she'd eat them, destroyed a pack of cigs. Loved to eat butts off ground so I suppose she had built up toleration for it.

I really thought she was a goner. I was really scared. It has been 6 days and she's really fine with pink gum, white in eyes, normal pee and poo. She's really fine. At least I can thank Johnson Creek 24 mg Tennenee Cured...

 

[Kate]

That's great Bryn, I'm glad Shania is doing well. If she was going to have problems they would have happened quickly - within a day.

It does sound like she's got some tolerance, lol, you'll have to watch she doesn't start searching out your nicotine for her addiction

 

[lbctsolutions]

so let's get this right... if I smoke 3x high cartridges @ 18mg a day, I am risking overdose?

I use a TECC Titan 510.....