There's a whole lot of interplay - again a lot of it is that turbulent airflow that is so important, and hard to define. It's going to be impacted by the chamber shape and size, the build, the drip tip, etc...
As some GENERAL rules:
- a smaller chamber is better at giving you "condensed" vapor - and therefore more flavor intensity. But it won't have room for "big" builds.
- a larger chamber gives you more total airflow capacity, and more room for big builds
- Big builds can provide more surface area, vaporizing more liquid at once, giving you bigger clouds
- Lower resistance can give more vapor, can also impact flavor, but tend to need more airflow to prevent burning
So - if you want intense flavor, you might go small chamber, but if you prefer a bit more vapor than you get with a tiny tiny atty - or you've moved to a "lung hit" and need some more airflow, that's where you get people shifting to the 22mm atties. And when they start making big fancy builds, they might want to try those oversized 24 or 30mm atties.
Again -that's generalization.
Me, I like a "restricted" lung hit. And I use all of these!
Cyclone with AFC
Origen Little 16
Nuppin! Nuppin! Nuppin! (I have three)
Rogue
Manta
M-atty
NarDa
I no longer like a tight draw, but also don't like a real airy or cool vape. All those above let me hit my "sweet spot" range - which is definitely a balancing act: airflow, vapor, flavor, response-time, heat...