Well I dont have any clinical data for you but here is my experience: I quit smoking for close to 4 years and used no nic whatsoever, I did however become a daily drinker (2 cases of beer a week) mainly becuase of anxiety issues. About a month ago I started vaping and my anxiety is gone. I have only had a few drinks in 4 weeks, and I was getting concerned that I was becoming an alchoholic. I had to have a drink soon as work was over, I often stopped on the way home and took a chance with an open container in order to get my fix. Since vaping I mysteriously have no need for a drink. I'm not sure how this fits in to the science of it but nic alone sure seems to do wonders for my anxiety. I feel more myself than I have in 4 years! Any explainations?