A few opinions I can't link to because they're from the vets forum:
From WillyB:
I guess it depends what you mean by "the safest". The safe chemistry cells most use are unprotected naked cells, they can be overcharged, overdrained and have no protection against shorts. In a simple tube PV (the current silly rage) hit them with a bad atty (dead short) and you better be be ready to pitch it. The new 'high end' mechanicals with no wires or springs (something to give and break the connection) are the worst.
From Off Topic:
WARNING:
If you are going to run a rebuildable atty on a mechanical mod, make sure you check the resistance on a meter before hooking it up to your device. If the resistance is below 1.3ohms, DO NOT PLUG IT IN.
Invest in a small ohm meter, or get a VV device with one built in. A protected battery covers all those possibilities.
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You decide.....