The drippers will give more vapor and, according to others, more flavor, I have bad taste and can not really tell the difference.
The Nautilus is a LOT easier.
With the dripper you need to build it yourself and change the wicking. Not hard after a little practice. You will need to cary around your mod and dripper, and a container of juice to drip. You can not drip and drive, you can but occasionally you will spill juice all over yourself.
Fill the Nautilus with 5 ml of juice and forget it. If you need a new coil just screw the old one out and the new one in.
If the dripper gets too dry you will get the taste, HORRIBLE, of burnt cotton with the hit. If you have sensative taste it is now time to change the wicking. If you drip too much you will have liquid coming out of the air holds and getting all over stuff.
I usually only drip at home and I take a rebuildable tank out and about with me. I also have a nautilus for when the rest of my stuff needs a little work and I do not feel like doing the work.