I think we all like to help people with mods no matter how elementary the question. We all feel the need to support everyone else who enjoys our hobby.
For a simple unregulated mod, two 14500's in parallel is going to get you closer to one 18650 in terms of run time and power delivery. However, with two 14500s, you get a flatter, more comfortable box. Though if you prefer a tube mod, the 18650 would be a better choice for run time and power delivery. There's one safety caveat with running removable batts in parallel so you need to be aware of it if you're going to do it.
With a regulated mod, you can go boost for increasing voltage or buck for decreasing voltage. However, buck gives you a wider voltage range and a much higher limit on atomizer power. Buck requires two batts in series. Boost requires one battery alone or two batts in parallel. Another option people are developing here is full PWM control, a simple and highly efficient way to control atomizer power, but you can't use a basic DC voltmeter to measure output. That one also requires two batts in series.