Couple things that are potentially going on here.
First of all, as you vape,
juice will tend to gunk up on the coil. How quickly this happens depends on your juice, particularly the VG content (higher VG *generally* = faster gunking). So it is, to some extent, normal for your resistance to rise a bit over the course of a few days/a week. To fix that, syringe the juice out and dry burn the coil (pulse fire the mod, a few seconds at a time with a few seconds between each firing, until you no longer see vapor and the coil looks clean). Your ohm reading should then "reset" to whatever it was when you first put the build in... and you'll get better flavor and more vapor, too.
What can cause your resistance to drop? Lots of things. Uneven coils. Hot spots. Coils that aren't well secured beneath the screws. Wire touching the deck. Sometimes, your stainless mesh's position in the tank (particularly if it's too close to the bottom of the tank or too close to the sides of the wick hole(s). Every atty (genny or otherwise) has its own "personality" as far as *exactly* how it vapes well, so you have to experiment and see what works for you/your genny.
So, check your screws (are they snug?), check the legs of your wires (are the legs heating up all the way up to where the wire goes beneath the screw? That's a "hot leg" and you'll get a much better vape if you fix it! You want the coil itself to glow red and the "legs" to not glow), and check to see if the coil is heating up evenly (is one part glowing brighter than the rest?).
When you've figured out which loop of your coil is causing the issue - and it usually is one particular little section - take a small heat proof implement (I usually use a safety pin), fire the mod so you can see where the problem is, *release the button* (very important - do not touch anything metal to the coil while the mod is firing!) and then, with your finger off the button, but before the coil has cooled, gently move the problematic section around. Even it up, if it's not even. Try gently pulling it to one side or another, or shifting the wick within the coil. Each time you try an adjustment, remove your poking implement from the coil, fire the mod, and see if anything has changed. Then, if it still doesn't look right, try something else.
With practice, you won't have to fiddle as much... you'll be able to wrap a coil, test fire it once, know what adjustments to make immediately, and be on your way.
It's worth mentioning that even once you've got it down, if you *drop* your mod, it's a good idea to double check the coil as soon as possible when you pick it back up. Sometimes the difference between a coil working consistently and not really is a difference of micrometers, so a fall off a desk or out of your pocket, while it may not damage anything, may be enough to knock your coil out of the alignment that works for you.... and it's better to find that out right after you've dropped it and thus know that dropping it was the cause for the erratic behavior, rather than making yourself crazy hours later trying to figure out why your perfect coil has suddenly decided to throw a tantrum, having forgotten that you dropped the thing.
Hope that helps.