Rapid Onset Nicotine Sensitivity

[YKruss]

In one study, nicotine administered to mice with tumors caused increases in tumor size (twofold increase), metastasis (nine-fold increase), and tumor recurrence (threefold increase)"

blahblahblah not a great read but focus on the part I put in bold. Yes it's one study and people can call it inconclusive or whatever but it's still a little scary. I don't ignore results like this as so many others choose to do to justify their continued addiction to nicotine.
.

I did focus on the bold part.

The original research was done in 2009 by NCI, National Cancer Institute, source PLOS ONE: Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer.

And that bold part in your post is from that research, which is also on Wikipedia page about nicotine.

But nobody updated Wikipedia with the latest findings.

And here is the latest press release from the same institute, NCI, about NIH (National Institute of Health) research done in 2011, source Low-dose nicotine does not promote lung tumors in mouse models - National Cancer Institute:

snip...
a limited body of research—including some tissue culture studies conducted by NCI scientists—has suggested that even low levels of nicotine might promote tumor growth. Those earlier findings raised potential concerns about the safety of using NRT. The results of the current study in mice found no evidence to support this concern.
snip...

 

[YKruss]

Deleted, double post.

 

[StormFinch]

Particle size has to do with whether the vapor gets to the lungs. the data so far suggest that the nicotine form vapor is absorbed primarily by the mucosa in the mouth and nose, and that most of the vapor doesn't reach as deep in the lungs as smoke does (though i think the vapor particle size is larger, but i could be wrong)

Nicotine might increase the blood flow to existing tumors by promoting the growth of new blood vessels (neovascularization), but it doesn't exactly cause cancers to "spread like crazy".

You're right on both counts CES, thanks for the correction. 1 micron for cigarette smoke versus ~10 microns for vapor.

I also remember reading the ongoing study with nicotine. It's the increased blood flow, which is why they are now looking at using nicotine to help diabetic neuropathy. For anyone that wants to google the info, the scientist quoted in my sig is one of the group doing studies in this area.

 

[ShogaNinja]

Actually, I had it backwards. I noticed this is being addressed further up the thread, but here's the word from Roly; http://www.e-cigarette-forum.com/forum/ecf-library/261114-tobacco-cigarette-vs-e-cigarette-nicotine-equivalency.html

I've seent it before. I hate that he doesn't link the actual studies. It takes a bit of credibility out of it, even though I usually regard everything he says as law because, well, he IS the law.

 

[ShogaNinja]

I did focus on the bold part.

The original research was done in 2009 by NCI, National Cancer Institute, source PLOS ONE: Nicotine Promotes Tumor Growth and Metastasis in Mouse Models of Lung Cancer.

And that bold part in your post is from that research, which is also on Wikipedia page about nicotine.

But nobody updated Wikipedia with the latest findings.

And here is the latest press release from the same institute, NCI, about NIH (National Institute of Health) research done in 2011, source Low-dose nicotine does not promote lung tumors in mouse models - National Cancer Institute:

Why don't you edit it then? Do the world a solid.

 

[YKruss]

Why don't you edit it then? Do the world a solid.

I don't care about Wikipedia.

I go to source researching important issues.

And I do like people doing the same before making any statements relying only on Wikipedia, specifically health related issues.

 

[allenwjones]

@StormFinch: Thank you for the correction on synthetic/isolated nicotine.. I will refine my previous statement: Whether my body chemistry will tolerate isolated nicotine or not without the presence of whole tobacco alkaloids is yet to be seen. I have ordered the WTA juice and it should arrive this week.

@mwa102464: I have not ever tried dip, patches, or gum to make any comparison.

@ShogaNinja: While the idea of DIY has certain benefits, I am more likely to go the route of zero nicotine juices for a time to satisfy the social aspects of being around smokers or just give it over entirely.. only time will tell that tale. However, I may choose to peruse the link you proposed at some point in the future.

"Having a simple vice is nice.. it keeps you from worse things." ~Author Unknown.

 

[allenwjones]

Update from over weekend:

· I deliberately vaped only on my 70/30 VG/PG zero nic juice over the weekend without any adverse effects.
· I received my order from Aroma with the WTA juice and have added about .2 ml to my zero mix in a 1.6ml carto.
· With this mix, I do not experience the same anxiety, but still notice a very high sensitivity to the content.

Looks like very low DIY or zero nic are my only options.
Thanks for all the feedback!

 

[CES]

Thanks for the update. Glad you've gotten some answers and found what is likely to work for you. There are vendors that will mix the PG/VG blend and nicotine level of your choice (i currently use 4-8mg/ml and purchase it rather than DIY. PM me if you'd like a link to the website of my favorite vendor in the world)

 

[allenwjones]

Glad you've gotten some answers and found what is likely to work for you.

Well, almost anyway. I still cannot figure out why I can smoke (and inhale) full cigars without any issue (and lots of enjoyment) but I cannot vape even the ultra-light versions of e-liquids without some kind of reaction. It is really too bad because some of the juices I have tried are far superior in flavor over tobacco analogues.. not to mention the social freedom vaporizers allow.

If anyone comes back to this thread with any additional ideas or similar experience I would be very grateful.

~Cheers!

 

[Tanya James]

Good luck hope all turns out well

 

[CES]

Well, almost anyway. I still cannot figure out why I can smoke (and inhale) full cigars without any issue (and lots of enjoyment) but I cannot vape even the ultra-light versions of e-liquids without some kind of reaction. It is really too bad because some of the juices I have tried are far superior in flavor over tobacco analogues.. not to mention the social freedom vaporizers allow.

If anyone comes back to this thread with any additional ideas or similar experience I would be very grateful.

~Cheers!

I don't know what the nicotine absorption is with cigars...i would guess lower than cigs, even if you inhale. But I don't know why you have a greater response with one and not the other, but considering that you had less anxiety with the WTA (if i read your post properly) maybe there's some interaction with the other elements in tobacco (tobacco alkaloids and MAOI's for example) that allows you to tolerate the nicotine better. But that's just a guess, since i don't know either.


Good luck!

 

[allenwjones]

I don't know what the nicotine absorption is with cigars...i would guess lower than cigs, even if you inhale. But I don't know why you have a greater response with one and not the other, but considering that you had less anxiety with the WTA (if i read your post properly) maybe there's some interaction with the other elements in tobacco (tobacco alkaloids and MAOI's for example) that allows you to tolerate the nicotine better.

I would not be surprised if this were the case, also I have considered that maybe something in the extraction process might leave some kind of residue my system does not like. Maybe someone will get smart and manufacture some organic e-liquid..

I have continued this topic in the Medical > Nicotine section here.

 

[baraxil]

Hello!

However, even with the lowest level of nicotine (6mg/ml) e-fluids I had noticed I have a very high sensitivity to the juice. What was more discouraging was that after one week of very limited use, the sensitivity increased to a point where I could not vape at all without experiencing higher levels of anxiety and tension as well as some dysphoria. When my sensitivity changed, it was very fast and the symptoms lasted for more than 2 hours, and at the worst point as much as a day.

Has anyone else experienced this kind of sensitivity, especially in this kind of timeframe?

I started vaping a week ago and I think we have similar problems. I bought the low 6 mg as well because I had tried other cheaper e cigarettes in the past with 16 mg nicotine I think it was and I had heart racing and anxiety and tension like you said. I thought I would be better with the lower nicotine. With the 6 mg on the first day I think I did too much and I had the same short of breath and even like 4 hours since my last vape I was sweating and my body was all tense and still struggling to breathe. Since the first day I am able to take a hit and then I get a little short of breathe and the tension but not as bad but I can only take a hit or 2 every 1-2 hours. I figure that maybe my body just has to get used to the different route of action of the nicotine and it will get better just like smoking cigarettes at first will make you dizzy maybe we just have to get used to the different things in the ejuices as well as the different artificial nicotine. And that I was also having short of breath with cigarettes that is why I wanted to switch so maybe my lungs just need to heal. I also know what you mean the dysphoria I feel kind of zoned out and super tired and extreme yawning I guess that could be lack of nicotine too.

Has anyone else had sensitivity to the ecig and then you get adapted to it? Has your vaping gotten better?

 

[allenwjones]

Thanks for the confirmation!

After two weeks of trying I gave it over until I can get some new information on whether or not this is something I want to risk. I would be very interested to know if your experience improves or if there are just some of us who just cannot use this technology.

 

[filter]

If you're just having a cigar or two on weekends, you probably have little or no nicotine tolerance.

im gonna have to go ahead and disagree with you there. i get five times the nic buzz from a cigar (without inhaling) than i do from vaping 24mg (inhaling) for the same amount of time. if i inhaled a cigar, i'd be on the floor. unless he's smoking cigars that are very small, very light in color and smoking them very slowly i can't imagine not having a heavy buzz. a typical medium-sized dark-colored cigar will have the average person laying down for about 20 mins after finishing it without inhaling. i would suggest you try inhaling a medium-sized medium-colored nicarguan cigar and see if you can stand up.

 

[CES]

im gonna have to go ahead and disagree with you there. i get five times the nic buzz from a cigar (without inhaling) than i do from vaping 24mg (inhaling) for the same amount of time. if i inhaled a cigar, i'd be on the floor. unless he's smoking cigars that are very small, very light in color and smoking them very slowly i can't imagine not having a heavy buzz. a typical medium-sized dark-colored cigar will have the average person laying down for about 20 mins after finishing it without inhaling. i would suggest you try inhaling a medium-sized medium-colored nicarguan cigar and see if you can stand up.

I'll take your word for it (just don't make me try it )

 

[baraxil]

Thanks for the confirmation!

After two weeks of trying I gave it over until I can get some new information on whether or not this is something I want to risk. I would be very interested to know if your experience improves or if there are just some of us who just cannot use this technology.

Hey man I can now chain vape with no problems on the 6mg. The nicotine seems to have less of an effect or something now and I don't get any rapid heart beat or anything. I think where I went wrong was I was doing 70 vg 30 pg because I thought VG was easier on your lungs or something but actually for me the pg is better on the lungs and the vg made me really tired. Now i'm doing 70pg/30vg

 

[baraxil]

Also something else I noticed before when I first had nicotine gum when I went on a trip because I couldn't smoke, It would make me feel like I was on speed or something and having a nicotine overdose and then once I used it for a few days I got more tolerant to it. I think its the different kind of nicotine or the new way of putting it in our bodies that it has to get used to.