So, let's think about this, really.
MANY people do 36mg e-liquid uncut. Do you *really* believe it only takes a 25% increase in potency to cause 'potentially significant bad effects' , e.g. 'hospital trip' etc?
I find that *highly* unlikely.
There's also the very likely case that you retain/absorb *significantly* less nicotine from e-vapor than from cigarettes, with a pack of cigs being ~22mg *absorbed* into the body.
36mg fluid is 36mg (provided) per 1ml (or gram, mostly equivalent/very close) of fluid. That is the size of a penstyle cart, approximately. However, studies are placing *absorption* rates (how much do you 'get') at up to 1/10th or less of vaped vs inhaled, and comments by vapers that were more than occasional smokers seem to support this - many vape more than they smoked. The comments here were based on 16mg liquid, so let's cut that in half, let's use the 1/5th just for examples purposes (nice even number for math).
That means your 1ml penstyle cart of 36mg, of which you only ever manage to get say, half, of the liquid out of the cart before needing top-off or refill, is now really .5ml, or 18mg, with only at most 3.6 mg absorbed out of it, roughly one penstyle cart until vapor reduction (say ~40-50 drags, or 3-4 analog inhale equivalents), and if you're vaping 'like a cigarette,' with say 12 inhales as a 'cigarette,' you're only getting .9 mg per 'cig equivalent', versus 1mg-1.8mg for a regular cigarette. 48mg using the same numbers, would put it at ~4.8 to be absorbed in the entire useful cartridge, and at 1.2mg for a 'equivalent puffs to real cig').
I suspect those numbers are actually even lower, but the point being, people chain-smoke real cigs all the time. Like alcohol poisoning, it is certainly possible to also get yourself sick on nicotine. However, paying attention goes a long ways, as does education. The 48mg liquid is *not* harmful by itself. I would not suggest *drinking* it, but at the doses we receive to our bodies, I would *gladly* buy a liter of 96mg today (which I would cut). That does *not* mean the bottles should not be labelled appropriately, but the 'world is not falling' by offering 48mg e-liquid or higher, assuming a purchaser is not entirely stupid.
Some reading:
http://www.e-cigarette-forum.com/fo...5034-nicotine-absorbtion-vaping-research.html
And read the *entirety* of this thread page 7 or so is where the new info shows up:
http://www.e-cigarette-forum.com/fo...nverting-e-cigs-regards-nicotine-content.html
While it would be nice if our governments/agencies were not so ignorant, or money driven, and I am all for getting *confirmed* data on e-cigs, nic absorption, liquid contents, etc...matters are not helped when we have vapers thinking the end is night because of something like 48mg liquid being available :-(