With a regulated mod, resistance does matter, but only in the sense of a) does your mod support that resistance (which it sounds like it does) and how much wattage you are trying to vape it at. Too high wattage can lead to less battery life, and more stress on the mod. I think however, you will be fine at your wattage range provided you use the appropriate batteries to support that wattage, which may mean higher Amps with lower mAh (runtime) but you don't want to stress your batteries. Mooch's blog will be helpful in figuring that out. However, it doesn't sound like you are trying to push everything to it's maximum limits, which is usually where folks run into issues, be it with a mech mod (more catastrophically) or a regulate mod which should (hopefully) just refuse to fire if you run into problems. But really, it's your batteries and wattage that are key to having a safe, enjoyable regulated experience.
Anna