When you have multiple batteries there are two ways you can wire them, series and parallel. In series the electrons flow from the negative of the first battery, through the load, back to the positive of the second battery, from the negative of the second battery to the positive of the first battery. You add the voltage of the two batteries and the amps stays the same. The problem here is that if the two cells do not have the same charge, number of electrons not voltage, one battery will run out first and the other will be carrying the load and put a large strain on them. More dangerous than a single battery. All the electrons go through both batteries.
In a parallel setup the electrons flow from the negative of both batteries through the load and back to the positive of both batteries. The voltage stays the same and you add the amps of the batteries. The two cells are kind of independent and are about as dangerous as a single battery. Half the electrons flow through each battery.
In tube mods the batteries are in series and in most, not all, box mods the batteries are in parallel. The DNA, DNA clones, and SX boards only support parallel, but some other box mods have the batteries in series to get higher voltages and use circuitry to drop the voltage.
In addition to not having the requirement for close matching of batteries in series parallel adds the amp rating of the batteries so you can get up to 60 amps form a pair of VTC4s.