Well, if the PV isn't rated for stacked batteries, don't use em stacked.
Also, it's stacked batteries when shorted that are the most iffy.
That said, the voltage is squared in the power calculations. Higher volts are supposed to be more efficient. This isn't accounting for device efficiency nor the differences in total battery mAh.
I use stacked 14500 Li Ion's (protected, and in a bucking voltage regulated vv mod) every day. They last a day and a half. That's at 4.8 ish volts and around 2.8-3.0 ohms.
The voltage regulator SHOULD be more efficient when bucking than when boosting <---- kind of a guess and it varies by device design.
I'm not sure I'm fond of stacking batteries in any tube mod though. The thing is...with stacking batteries you're limited to the max-amp rating of a SINGLE battery. So that's when shorts at the higher voltage exceed the C rating of the battery quicker (all shorts exceed the rating, but this would be double the oomph due to stacking).
That's why I use protected batteries in my box mod. That gives me THREE trip points...one on each battery and one for the voltage regulator that has over-current protection. Also the box mod can't build up internal pressure because the back just slides off.
Anyway, OP. A lot depends on the efficiency of the mod's circuits. And features cost. Also safety costs...IMR's hold less charge but are required for booster mods.
Mine, as a buck mod, is more efficient at higher voltages. However, it can't boost. And has no frills.
Get a few spare 18650's. Good ones. And maybe a plastic carrying case or an old pill bottle or three.
EE's could tell you more. Theoretically, higher voltage (and associated higher ohms to similar watts not more watts) are more efficient. Design matters. But safety counts too.